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Newly described horned dinosaur from New Mexico was the earliest of its kind


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Menefeeceratops sealeyi adds important information to scientists’ understanding of the evolution of ceratopsid dinosaurs, which are characterized by horns and frills, along with beaked faces. In particular, the discovery sheds light on the centrosaurine subfamily of horned dinosaurs, of which
Menefeeceratops is believed to be the oldest member. Its remains offer a clearer picture of the group’s evolutionary path before it went extinct at the end of the Cretaceous.
Steven Jasinski, who recently completed his Ph.D. in Penn’s Department of Earth and Environmental Science in the School of Arts & Sciences, and Peter Dodson of the School of Veterinary Medicine and Penn Arts & Sciences, collaborated on the work, which was led by Sebastian Dalman of the New Mexico Museum of Natural History and Science. Spencer Lucas and Asher Lichtig of the New Mexico Museum of Natural History and Science in Albuquerque were also part of the research team. ....

United States , University Of Pennsylvania , New Mexico , New Mexico Museum Of Natural History , Peter Dodson , Sebastiang Dalman , Asher Lichtig , Sebastian Dalman , Tom Williamson , Paul Sealey , Stevene Jasinski , Steven Jasinski , Spencer Lucas , Upenn Arts Sciences , Department Of Earth , School Of Veterinary Medicine , University Of Pennsylvania School Arts Sciences , Harrisburg University Of Science , Mexico Museum Of Natural History , School Of Arts Sciences , Museum Of Pennsylvania , Penn Department Of Earth , Environmental Science , Veterinary Medicine , Penn Arts , New Mexico Museum ,

Parkinson's disease risk and severity is tied to a channel in cells' 'recycling centers


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Many genetic mutations have been found to be associated with a person s risk of developing Parkinson s disease. Yet for most of these variants, the mechanism through which they act remains unclear.
Now a new study in
Nature led by a team from the University of Pennsylvania has revealed how two different variations one that increases disease risk and leads to more severe disease in people who develop Parkinson s and another that reduces risk manifest in the body.
The work, led by Dejian Ren, a professor in the School of Arts & Sciences Department of Biology, showed that the variation that raises disease risk, which about 17% of people possess, causes a reduction in function of an ion channel in cellular organelles called lysosomes, also known as cells waste removal and recycling centers. Meanwhile, a different variation that reduces Parkinson s disease risk by about 20% and is present in 7% of the general population enhances the activity of the same ion ....

Alices Chen Plotkin , Yuling Liang , Thomasf Tropea , Boxun Lu , Huanhuan Wang , Alice Chen Plotkin , Joey Lohmann , Zhenjiang Liu , Chunlei Cang , Dejian Ren , Kelvinc Luk , Kimberly Aranda , Jinhong Wie , Kelvin Luk , China Fudan University , National Institutes Of Health , China Peking University , University Of Pennsylvania School Arts Sciences , Penn Perelman School Of Medicine , University Of Pennsylvania , School Of Arts Science Department Biology , Penn School Of Arts Sciences , Science Department , Pennsylvania School , Perelman School , Haikun Song ,

First ever 'pioneer' factor found in plants enables cells to change their fate


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IMAGE: Using an experimental technique whereby flowers can be coaxed to form from plant roots, biologists led by the University of Pennsylvania s Doris Wagner uncovered a protein that enables for the.
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Credit: University of Pennsylvania
Cells don t express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn t need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.
These unneeded genes are kept from becoming active by being stowed in dense chromatin, a tightly packed bundle of genetic material laced with proteins. ....

Doris Wagner , Meilin Fernandez Garcia , Kenneth Zaret , Roberti Williams , Adam Konkol , Samantha Klasfeld , Yang Zhu , Jun Xiao , Nature Communications , School Of Arts Sciences , Upenn Perlman School Of Medicine , University Of Pennsylvania , University Of Pennsylvania School Arts Sciences , Perelman School Of Medicine , Penn School Of Arts Sciences , Perelman School , Term Professor , Pennsylvania School , Run Jin , Soon Ki Han , Perlman School , National Science Foundation Division , Integrated Organismal Systems , டோரிஸ் வாக்னர் , ரொபேர்த்ி வில்லியம்ஸ் , யாங் ஜு ,