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Hergott, Burton, Love, Hawkins share AP Ky. All-State honors


Hergott, Burton, Love, Hawkins share AP Ky. All-State honors
By GARY B. GRAVESApril 15, 2021 GMT
Dual-threat quarterback Cameron Hergott of Kentucky Class 2A champion Beechwood High School and Frederick Douglass two-way lineman Jager Burton have been selected as Kentucky’s co-Mr. Football for the COVID-19-shortened 2020 season.
Tony Love and Phillip Hawkins shared coach of the year honors in voting by members of The Associated Press from around the state. Love guided Class 3A Ashland Blazer (11-0) to its first state championship since 1990, while Hawkins led Bryan Station to the Class 6A quarterfinal after a 3-8 finish in 2019.
Hergott, 6-foot-2, combined for 3,554 yards and 41 touchdowns offensively last season while leading the powerhouse Tigers (10-2) to their first 2A championship after 14 1A titles. He threw for 2,467 yards and 26 TDs, including 154 with two scores on 12-of-26 passing as Beechwood topped Lexington Christian 24-23 in overtime for the champion ....

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Pharma Looks to Inflammasome Inhibitors as All-Around Therapies


Heart failure, gout, COVID-19, melanoma
Completed Phase 1 and Phase 1b in patients with heart failure and Phase 2a in patients with acute gout flares. A Phase 2 trial for people with moderate COVID-19 symptoms is ongoing, and the company is planning a Phase 2 trial in late-stage melanoma, along with an approved immunotherapy.
Drugging the inflammasome
For years after the inflammasome’s initial discovery, the search for drugs that target it yielded no promising leads, Cooper says. “Big pharma all went and screened their libraries of drugs and said, can we find an inhibitor? But no one could.” 
Several years ago, that began to change. Luke O’Neill, an immunologist at Trinity College Dublin, was one of the people searching for an NLRP3 inhibitor, with colleagues at his company Opsona. He knew that a scientist named Chris Gabel had been working at Pfizer in the late 1990s on a molecule called CRID3, which appeared to block IL-1β production. O’Neill was int ....

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As nation braces for armed protests, Arizona showcases how First and Second amendments intersect — or collide


As nation braces for armed protests, Arizona showcases how First and Second amendments intersect or collide
John D Anna, Arizona Republic
Last week, as insurrectionists stormed the seat of democracy, a smaller crowd – nowhere near as violent but just as angry – gathered at the Arizona Capitol to protest the results of the 2020 presidential election. Many were armed.
In September, more than 300 counter-protesters, many carrying AR-15s and side arms, showed up at a Black Lives Matter rally in Prescott, saying they intended to protect their community from rioting and looting.
And earlier last summer, four men armed with assault-style weapons showed up in downtown Mesa under the guise of protecting local businesses during street protests in the wake of the death of George Floyd. ....

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