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McMaster lab has screened hundreds of samples for rare blood clots linked to AstraZeneca vaccine

Hundreds of samples have passed through a McMaster University lab over in recent weeks, scrutinized by a team of doctors for a rare, blood-clotting syndrome that has been linked to the AstraZeneca-Oxford COVID-19 vaccine. ....

Barbara Yaffe , Ishac Nazy , Mcmaster University , Members Of The Platelet Immunology Laboratory , Platelet Immunology Laboratory , பார்பரா யாஃப் , மக்மாஸ்டர் பல்கலைக்கழகம் , பிளேட்லெட் நோயெதிர்ப்பு ஆய்வகம் ,

The latest on the coronavirus outbreak for April 19

Pandemic rise of virtual care and telemedicine could bring with it climate benefits, researchers say.
Tears for family members, relief for airlines as Australia-New Zealand travel routes increase significantly.
Read more: Follow all the details and analysis of the federal budget announcement; Canadian new housing starts for March easily beat analyst expectations.
Motorists are stopped at a police checkpoint in Ottawa on Monday as new COVID-19 restrictions came into effect that limit travel into the province of Ontario. (Patrick Doyle/Reuters)
Some provinces begin to expand AstraZeneca vaccine eligibility
Manitoba on Monday followed on the heels of Ontario and Alberta by announcing that anyone aged 40 and up is now eligible to receive the AstraZeneca-Oxford coronavirus vaccine. ....

New Zealand General , New Zealand , New South Wales , United Kingdom , British Columbia , New Brunswick , Bailey Howard , Ishac Nazy , Richard Shearmur , John Tory , Marianne Dawson , John Kelton , Jacinda Ardern , Astrazeneca Covishield , Tim Lang , Patty Hajdu , David Macdonald , Sean Christie , Carrie Hurihanganui , Donald Arnold , Supriya Sharma , Scott Morrison , Danny Mather , Canadian Medical Association , Canadian Centre For Policy Alternatives , Labour Force ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

IgG antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anti-cancer therapeutic antibodies for their elevated activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated IgG (~6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcγRIIIa responses, but also amplifies brewing cytokine storms and immune-mediated pathologies. Critically ill COVID-19 patients, but not those with mild symptoms, had high levels of afucosylated IgG antibodies against SARS-CoV-2, amplifying pro-inflammatory cytokine release and acute phase responses. Thus, antibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-19. ....

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Assaymap Bravo Agilent , Bruker Daltonics , Santa Clara , Academic Medical Center , Reagent Program , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg , Proteing Sepharose , Millipore Multiscreen , Agilent Technologies ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , European Union Seventh Framework Programme Highglycan , Immunity Institute , Netherlands National Institute For Public Health , Monitoring Foundation , Ethics Committee Of The University Amsterdam , Discovery Workbench Software , Ge Healthcare , Netherlands Organization For Scientific Research , Reagent Program , Amsterdam Health Service , Windows Graphpad Software Inc , Sanquin Blood Supply Foundation , Platelet Immunology Laboratory , Afucosylated Igg Responses , Total Igg , Afucosylated Igg ,

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Noord Holland , United States , United Kingdom , Uppsala Lan , Eteläuomen Läi , Bruker Daltonics , Assaymap Bravo Agilent , U Cytech Biosciences , Santa Clara , Academic Medical Center , Reagent Program , Windows Graphpad Software Inc , Ethics Committee Of The University Amsterdam , Platelet Immunology Laboratory , Discovery Workbench Software , Ge Healthcare , Afucosylated Igg Responses , Total Igg , Afucosylated Igg , Plasmad Dimer , Amsterdam Cohort Studies , Finnish Red Cross Blood , Medical Ethics Committee , Cytomegalovirus Igg , Measles Igg , Mumps Igg ,