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UK project looks to transform oligonucleotide medicines manufacturing


UK project looks to transform oligonucleotide medicines manufacturing
UK catalyst organization, CPI, has announced the launch of a project that aims to revolutionize the manufacture of oligonucleotides, through a collaboration involving, among others, AstraZeneca, Exactmer, and Novartis.
The partners are looking to develop a scalable, sustainable and more cost-effective medicines manufacturing process for oligonucleotides: short strands of synthetic DNA or RNA. They will utilize their combined expertise across scale-up, analytics and process development to achieve those goals.
Oligonucleotides, which are short strands of synthetic DNA or RNA, can be used as medicines by interfering with how genes are expressed. While they have shown success in the treatment of rare diseases, this next-generation therapeutic class is now being explored to treat chronic diseases that affect much larger patient populations, said CPI.  ....

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Scientists identify genomic signatures of long-term survival in luminal breast cancer patients


Scientists identify genomic signatures of long-term survival in luminal breast cancer patients
Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analyzed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques.
Carried out by Lydia King during her studies in NUI Galway s MSc in Biomedical Genomics programme, the research has been published in the international journal
PLOS ONE.
Early detection by national screening programmes and timely treatment for patients diagnosed with luminal types of breast cancer have resulted in excellent prognoses with survival rates of over 80% within five years of treatment. The challenge of long-term survival however is not as well understood and studies have shown that more than half of all recurrences for luminal breast cancers take ....

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