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Targeting mechanosensitive protein could treat pulmonary fibrosis, study suggests


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IMAGE: Compared with a control (left), removal of the Mdm4 gene (right) favors the resolution of fibrotic scar tissue in the lungs of aged mice.
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Credit: ©2021 Qu et al. Originally published in
Journal of Experimental Medicine. https://doi.org/10.1084/jem.20202033
Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially treat the deadly, aging-related lung disease idiopathic pulmonary fibrosis (IPF). The study, which will be published March 10 in the
JEM), suggests that targeting a protein called MDM4 could prevent respiratory failure by initiating a genetic program that removes scar tissue from the lungs. ....

Rockefeller University , New York , United States , Department Of Medicine , University Of Alabama At Birmingham , Experimental Medicine , Rockefeller University Press , Cell Biology , Medicine Health , Pulmonary Respiratory Medicine , ராக்ஃபெல்லர் பல்கலைக்கழகம் , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம் , சோதனை மருந்து , ராக்ஃபெல்லர் பல்கலைக்கழகம் ப்ரெஸ் , உயிர் வேதியியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , நுரையீரல் சுவாச மருந்து ,

Potential drug for Alzheimer's disease prevention found safe and effective in animals


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IMAGE: Compared with a control (left), treatment with the novel GSM (right) reduces the number of amyloid plaques (green) and proinflammatory cells called microglia (magenta) in the brains of mice carrying.
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Credit: ©2021 Rynearson et al. Originally published in
Journal of Experimental Medicine. https://doi.org/10.1084/jem.20202560
Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer s disease by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques in the brain. The study, which will be published March 2 in the
JEM), demonstrates that the drug is safe and effective in rodents and monkeys, paving the way for future clinical trials in humans. ....

New York , United States , San Diego , Rockefeller University , University Of California San Diego , Stevenl Wagner , Rudolphe Tanzi , Department Of Neurosciences , Uc San Diego School Of Medicine , California San Diego School , Massachusetts General Hospital , Experimental Medicine , Diego School , Massachusetts General , Rockefeller University Press , Cell Biology , Medicine Health , Alzheimers Disease , Pharmaceutical Science , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , ராக்ஃபெல்லர் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , துறை ஆஃப் நரம்பியல் , அக் சான் டியாகோ பள்ளி ஆஃப் மருந்து ,