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New map reveals genes that control the skeleton


Credit: Garvan Institute of Medical Research
Research led by the Garvan Institute of Medical Research has for the first time mapped the unique genetic profile of the skeleton s master regulator cells, known as osteocytes.
The study published today in
Nature Communications outlines the genes that are switched on or off in osteocytes, a type of bone cell that controls how other types of cells make or break down parts of the skeleton to maintain strong and healthy bones.
This new information provides a kind of genetic shortlist we can look to when diagnosing bone diseases that have a genetic component, says the study s first author Dr Scott Youlten, Research Officer in the Bone Biology Lab. Identifying this unique genetic pattern will also help us find new therapies for bone disease and better understand the impacts of current therapies on the skeleton. ....

New York , United States , United Kingdom , City Of , Janice Gibson , Scott Youlten , Peter Croucher , King College London , Nature Communications , Garvan Institute , Bone Biology Lab , York Genome Center , Wellcome Trust Strategic Award , University Of Queensland , Head Of The Bone Biology Lab , Garvan Institute Of Medical Research , Imperial College London , Wellcome Trust Sanger Institute , Ernest Heine Family Foundation , Institute Of Translational Genomics , Mcgill University , Medical Research , Research Officer , Bone Biology , Professor Peter Croucher , Deputy Director ,

For next pandemic we need vaccines in 100 days, says expert


Developing Covid-19 vaccines in less than a year came from repurposing multiple, decade-old vaccine research platforms, but too many lives were lost, and a new goal of developing vaccines in 100 days is needed to counter the next global pathogen.
This is according to Dr Nicole Lurie, a Strategic Advisor to the UK-based Coalition for Epidemic Preparedness Innovations (CEPI), and an advisor to the World Bank and the World Health Organization, (WHO).
She was addressing a virtual global forum on tuberculosis (TB) vaccines on Thursday, 22 April, in a session on how to use lessons from Covid-19 to accelerate responses to the TB burden and antimicrobial resistance worldwide. ....

Cape Town , Western Cape , South Africa , United States , United Kingdom , Nicole Lurie , Erica Andersen Nissen , Gordon Dougan , Jim Kublin , United Coalition For Epidemic Preparedness Innovations , Sa Variant Consortium , Mental Health , World Health Organization , World Bank , Head Of Pathogen Research , Wellcome Trust Sanger Institute , African Union , Fred Hutchinson Cancer Research Centre , Immunology Laboratory , Vaccine Trials Network , Strategic Advisor , United Kingdom Based Coalition , Epidemic Preparedness Innovations , Professor Gordon Dougan , Pathogen Research , Executive Director ,