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Basic cell health systems wear down in Huntington's disease, analysis shows

Basic cell health systems wear down in Huntington’s disease, analysis shows
February 26, 2021MIT
A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.
Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage from the disease pathology itself.
The analysis yielded a trove of specific gene networks governing molecular pathways that disease researchers may now be able to target to better sustain brain cell health amid the devastating neurodegenerative disorder, says co-senior author Myriam Heiman, associate professor in MIT’s Department of Brain and Cognitive Sciences and an investigator at The Picower In ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , மியிரியம் ஹெய்மன் , மேரி வேரத்ஜு ,

Basic cell health systems wear down in Huntington's disease, analysis shows

Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , University Of California , Immune Response ,

Basic cell health systems wear down in Huntington's disease, analysis shows | MIT News | Massachusetts Institute of Technology

Caption:
Researchers employed a software system called Geomic to integrate vast amounts of gene expression data from the brains of mice modeling Huntington s disease. By comparing multidimensional mathematical surfaces plotted from the data, they were able to gain new insights into how gene expression differs in the disease based on many dimensions such as time, cell type and the extent of mutation in the huntingtin gene.
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Image: Lucile Megret/Sorbonne Universite
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Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage from the disease pathology itself. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , Picower Institute For Learning And Memory , Huntington Amp 039s Disease ,

Basic cell health systems wear down in Huntington's disease, novel analysis shows

A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis. The Geomic approach can be applied to other diseases, authors say. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Associate Professor , Picower Institute , Centre National De La Recherche Scientifique , National Institutes , Molecular Biology , Mathematics Statistics , Medicine Health ,

Dead in the Water | Hakai Magazine

This article was originally published in
High Country News, a magazine about the American West’s environment and communities. Read more stories like this at hcn.org.
The
Lumberman, a 33-meter Second World War–era steel-hull tugboat, has been floating at the quiet cruise ship dock in Juneau, Alaska, for months, awaiting a watery grave. Abandoned for nearly a decade, the
Lumberman was moored in Juneau’s Gastineau Channel in the early 2000s by its last owner, Brenden Mattson. Two years ago, the tugboat’s anchor line broke, stranding it on state tidelands and creating a jurisdictional hot potato for city, state, and coast guard officials as they debated how to dispose of the vessel. ....

United States , Environmental Protection Agency , District Of Columbia , United Kingdom , Brenden Mattson , Aaron Timian , Matthew Creswell , Hilary Wilkinson , Washington State Department Of Natural Resources , Mckinley Research Group , Pacific States British Columbia Oil Spill Task , High Country News , American West , Second World War , Gastineau Channel , Juneau Docks , Alaska Based Mckinley Research , British Columbia Oil Spill Task Force , Washington State Department , Natural Resources , West Coast , ஒன்றுபட்டது மாநிலங்களில் , மாவட்டம் ஆஃப் கொலம்பியா , ஒன்றுபட்டது கிஂக்டம் , பிரெண்டன் மேட்சன் , ஆரோன் டைமியன் ,