coming. obviously nobody can anticipate the specific next variant to come, what the protein will look like et cetera but in a more general sense did you not see variants coming? >> we did, jake, we definitely saw variants coming. i think we referred to what was not anticipated was the extent of the mutations and the amino acid substitutions in omicron which is really unprecedented. it kind of came out of nowhere, you have a virus 50 mutations, to me it's really quite unprecedented so that's something you would not have anticipated, but we certainly were anticipating that there were going to be variants. when you have so many virus, so much replication going on in the community, if you give a virus enough opportunity to replicate,