of your brain can make it hard to lose weight? contrave is an fda-approved weight-loss medicine that may help adults who are overweight or struggle with obesity lose weight and keep it off. contrave is believed to work on two areas of the brain: your hunger center... (woman) i'm so hungry. (avo) to reduce hunger. and your reward system... (woman) ice cream. french fries. (avo) to help control cravings. across three long-term studies, contrave patients lost approximately 2-4x more weight than with diet and exercise alone. contrave is not for everyone. one ingredient in contrave may increase suicidal thoughts or actions in some children, teens, and young adults within the first few months. other serious side effects include seizures, increase in blood pressure or heart rate, liver damage, manic episodes, glaucoma and allergic reactions. do not take with opioids. reduce hunger, help control cravings. contrave. the #1 prescribed weight-loss brand.