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like a better word. they reasoned basis for a lot of bison. can you talk a bit more about that what was happening in the 18th and 19th centuries? >> absolutely. as you said, opium was a common ingredient in a lot of different medications. one of the most frequent uses was called latina. this was something regularly prescribed for pain medication for pain tolerance of someone was ill or had trouble sleeping. so for example we know that two first ladies in the 19th century died while their husbands were in the white house, letitia tyler and carole harrison. we don't know what they were prescribed log and was so common at the time that's hard to imagine that was one of the things that suggested. similarly, one of my favorite colorful stories occurred in 1805, when one of the first and only impeachment proceedings of a supreme court justice took place. john randolph was in charge of the prosecution of that case. he had such bad stomach issues