The 13 Greatest Science Fiction Comedies Of All Time Alasdair Wilkins and Charlie Jane Anders On Friday, Guardians of the Galaxy hits theaters, with its unique blend of space-opera and insane comedy. Which classic films must Guardians defeat to take its place among the greatest science fiction comedies? Here are the 13 greatest (live-action) science fiction comedies of all time. Advertisement The Particulars: The film flopped on its initial release, providing yet more evidence that, as a general rule, big budget comedies just don't do very well at the box office. For all its pyrotechnics, Mystery Men is really just an alternative comedy with surprising insight into the superhero genre. If I'm being honest,