The competition and rivalry in the Transatlantic relations have become too costly to continue. Biden’s administration means a new opportunity for the EU to rebuild its ties with the United States and reverse the tide of rising illiberalism and authoritarian rule globally, particularly in the EU’s neighbourhood. The Central and Eastern European (CEE) countries might positively contribute to the restarting relationship and bring their know-how and experience in working with Eastern Partnership and Western Balkans. The declared priorities of establishing an alliance of world democracies, fighting foreign corruption and interference, and working on democratisation and human rights can make a difference in both regions and bring concrete benefits to the bilateral relations.