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Abstract We report 3 cases of Puumala virus infection in a family in Switzerland in January 2019. Clinical manifestations of the infection ranged from mild influenza-like illness to fatal disease. This cluster illustrates the wide range of clinical manifestations of Old World hantavirus infections and the challenge of diagnosing travel-related hemorrhagic fevers. Puumala orthohantavirus (PUUV), a species of the genus Orthohantavirus within the Hantaviridae family, is an enveloped single-strand negative-sense RNA virus ( 1). The case-fatality ratio of Old World hantaviruses ranges from 1%–...

Abstract Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations ( 20) in the viral capsid protein 1–encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably 3 years) before being isolated. ...

Plasmodium falciparum populations from Sudan, South Sudan, Nigeria, and Eritrea (A), and pfhrp2 and ... We amplified and scored 7 microsatellite loci for each sample from Sudan, South Sudan, and Nigeria (n = 86), finding 88 unique haplotypes. Two samples shared a haplotype, and we observed 2 instances of multiple haplotype infection. All 7 microsatellite markers were found to be polymorphic. We found a mean of 11 alleles per locus, a range from 6 (microsatellite markers TA109 and 2490) to 16 (microsatellite marker 383) distinct alleles. We found the genetic relatedness of P. falciparum popu...

Norovirus GII.4 viruses have caused most gastroenteric infections for >2 decades, and new variants have emerged every 2–4 years since 2002 ( 7). Six pandemic GII.4 variants have been named after the place of first reported sequence and year of predominance: US 95–96, Farmington Hills 2002, Hunter 2004, Den Haag 2006, New Orleans 2009, and Sydney 2012. Several norovirus vaccine candidates are in preclinical studies and clinical trials ( 8); however, it is currently unclear if these vaccine formulations could protect against newly emerging GII.4 viruses that are often associated with more n...

3), so vector roles of both species should not be overlooked. TBRF courses with febrile episodes and should be considered as a differential diagnosis within the spectrum of diseases that cause an undifferentiated febrile syndrome (UFS) ( 6). Although specific data are vague for the states where tick collections were performed in this study, UFS is common in Brazil; mosquitoborne viruses and malaria are the main etiologic agents ( 8). Nevertheless, febrile illnesses still remain underdiagnosed in a substantial proportion of the cases in the country ( 8). The results of this study are a contrib...