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Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study

Objectives To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia at baseline.

Design Retrospective cohort study using large scale hospital administrative data.

Setting Public and private hospitals in New South Wales, Australia between July 2001 and March 2020.

Participants Data were extracted for 650 590 hospital patients aged ≥65 years. Diagnoses of dementia and delirium were identified from ICD-10 (international classification of diseases, 10th revision) codes. Patients with dementia at baseline were excluded. Delirium-no delirium pairs were identified by matching personal and clinical characteristics, and were followed for more than five years.

Main outcome measures Cox proportional hazards models and Fine-Gray hazard models were used to estimate the associations of delirium with death and incident dementia, respectively. Delirium-outcome dose-response associations were quantified, all analyses were performed in men and women separately, and sensitivity analyses were conducted.

Results The study included 55 211 matched pairs (48% men, mean age 83.4 years, standard deviation 6.5 years). Collectively, 58% (n=63 929) of patients died and 17% (n=19 117) had a newly reported dementia diagnosis during 5.25 years of follow-up. Patients with delirium had 39% higher risk of death (hazard ratio 1.39, 95% confidence interval 1.37 to 1.41) and three times higher risk of incident dementia (subdistribution hazard ratio 3.00, 95% confidence interval 2.91 to 3.10) than patients without delirium. The association with dementia was stronger in men (P=0.004). Each additional episode of delirium was associated with a 20% increased risk of dementia (subdistribution hazard ratio 1.20, 95% confidence interval 1.18 to 1.23).

Conclusions The study findings suggest delirium was a strong risk factor for death and incident dementia among older adult patients. The data support a causal interpretation of the association between delirium and dementia. The clinical implications of delirium as a potentially modifiable risk factor for dementia are substantial.

The data used in this study are available to the public through application to the Centre for Health Record Linkage (see [www.cherel.org.au][1] for more information). The analysis script (R markdown file) is available for download from <https://espace.library.uq.edu.au/view/UQ:dfc4e74>

[1]: http://www.cherel.org.au

Australia , Australian , Shlomo-berkovsky , Ruthe-hubbard , Hao-xiong , Emilyh-gordon , Australian-frailty-network , Partnership-centre-for-health-systems-sustainability , Partnership-centre-for-health-system-sustainability , Centre-for-health-record-linkage , Health-records , Hospital-elder-life-program

MIL-Evening Report: Voluntary assisted dying is different to suicide. But federal laws conflate them and restrict access to telehealth

MIL-Evening Report: Voluntary assisted dying is different to suicide. But federal laws conflate them and restrict access to telehealth
foreignaffairs.co.nz - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from foreignaffairs.co.nz Daily Mail and Mail on Sunday newspapers.

University-of-adelaide , South-australia , Australia , Australian-capital-territory , Australian , Kate-chaney , Michaela-estelle-okninski , Marc-trabsky , Nicholas-carr , Australasian-association-of-bioethics , Health-law , Recommended-sponsor-painted-moon

SIT Engineering Tutor Presents Research Internationally

SIT | Te Pūkenga Programme Manager and Engineering Tutor Carlo Gabriel presented his research internationally when he attended the recent Australasian Association of Engineering Education (AAEE) Conference. Held on the Gold Coast, Australia, December ...

United-kingdom , Australia , Sydney , New-south-wales , Sweden , New-zealand , Canada , Ghana , Canadian , Gold-coast , Carlo-gabriel , Australasian-association-of-engineering-education

Community Scoop » SIT Engineering Tutor Presents Research Internationally

Scoop Community provides New Zealand Community news and views

Canada , Sydney , New-south-wales , Australia , New-zealand , Ghana , Sweden , United-kingdom , Gold-coast , Canadian , Carlo-gabriel , Te-pkenga-programme

The Tertangala Prose and Poetry Contest -

Looking for a writing contest that values your unconventional ideas? Want a chance to experiment with your writing AND get praise for it? The Tertangala Prose

Illawarra , Victoria , Australia , Joshua-lobb , Hayely-scrivenor , Christine-howe , Master-in-creative-writing-at-oxford-university , University-of-wollongong , Google , Australasian-association-of-writing-programs , Coast-writers-center , Tertangala-prose

Theatre Professor awarded 2024 Kiwibank Local Hero medal

Professor O’Donnell is a pillar of the Te Herenga Waka—Victoria University of Wellington theatre community, and has demonstrated passion and vibrancy in his teaching over more than two decades.Described by Kiwibank as “one of those remarkable and uni

Jordan , New-zealand , Phil-mann , Nicola-hyland , Sarah-ross , Herenga-waka , Victoria-university-of-wellington , Theatre-programme , Pouakorangi-programme , Australasian-association-for-theatre , Head-of-school , Kiwibank

Beijing accused of meddling in Taiwan's election by offering massive flight discounts for voters on the mainland

Beijing accused of meddling in Taiwan's election by offering massive flight discounts for voters on the mainland
abc.net.au - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from abc.net.au Daily Mail and Mail on Sunday newspapers.

Taiwan , Hong-kong , Melbourne , Victoria , Australia , Shanghai , China , Taiwan-strait , Taiwan-general- , Beijing , Taipei , T-ai-pei

Australian retail lobby groups refuse to disclose amount of funding from tobacco and vaping industries

Representatives for convenience and grocery stores tell Senate inquiry details of any funding were commercial in confidence

Australia , Australian , Geraldine-mellet , Theo-foukkare , Marielle-smith , David-pocock , Senate-committee , World-health-organization , Australian-council-on-smoking , Australasian-association-of-convenience-stores , Senate-inquiry-or-mr-foukkare , Australasian-association

The tobacco industry claims smoking reforms fuel the black market. Health experts say this is wrong

Proposed changes such as plain packaging for vapes and individual cigarette warnings come under microscope at Senate hearing

Sydney , New-south-wales , Australia , United-states , Australians , American , Australian , Theo-foukkare , Marielle-smith , Becky-freeman , Michelle-scollo , Philip-morris

Acclaimed Cognitive Researcher Dr. Inês Hipólito Joins VERSES as Artificial Intelligence (AI) Ethicist

VANCOUVER, British Columbia, Aug. 10, 2023 (GLOBE NEWSWIRE) -- VERSES AI Inc. (CBOE:VERS) (OTCQX:VRSSF) ("VERSES'' or the "Company”), a cognitive computing company specializing in the next generation of artificial intelligence, strengthens its commitment to ethical AI by proudly introducing Dr. Inês Hipólito as AI Ethicist. Dr. Hipólito, an internationally renowned researcher in cognitive neuroscience and AI, brings her knowledge and experience to VERSES, championing the integration of ethical c

United-kingdom , Berlin , Germany , Vancouver , British-columbia , Canada , Australia , Sydney , New-south-wales , Amsterdam , Noord-holland , Netherlands