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New cellular atlas maps out healthy and cancerous breast tissue


Date Time
New cellular atlas maps out healthy and cancerous breast tissue
WEHI researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.
The diversity of cells in the human breast has been
documented in a new ‘RNA atlas’.
The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an ‘RNA atlas’ that details the different cells found in these tissues. ....

Tony Papenfuss , Jane Visvader , Geoff Lindeman , Gordon Smyth , Yunshun Chen , Rachel Joyce , Bhupinder Pal , Stephen Wilcox , Jocelyn Penington , Vanessa Bryant , Nina Tubau Ribera , Bianca Capaldo , National Health , Qualtrough Cancer Research Fund , Michael Heine Family Foundation , Ian Potter Foundation , Australian Cancer Research Foundation , National Breast Cancer Foundation , Research Council , Olivia Newton John Cancer Research Institute , Professor Jane Visvader , Professor Gordon Smyth , Professor Geoff , Professor Visvader , Professor Smyth , Victorian Cancer Biobank ,

The Achilles heel of the coronavirus


Credit: Said Sannuga, Cellscape.co.uk / ETH Zurich, The Ban Lab
Viruses require the resources of an infected cell to replicate and then infect further cells, and transfer to other individuals. One essential step in the viral life cycle is the production of new viral proteins based on the instructions in the viral RNA genome. Following these construction plans, the cell s own protein synthesis machine, called the ribosome, produces the viral proteins.
In the absence of viral infection, the ribosome moves along the RNA in strictly defined steps, reading three letters of RNA at a time. This three-letter code defines the corresponding amino acid that is being attached to the growing protein. It almost never happens that the ribosome slips one or two RNA letters forward or backward instead of following the regular three-letter steps. When such a slip of the ribosome occurs, it is called a frameshift, and it leads to an incorrect reading of the genetic code. ....

Nenad Ban , National Center , University Of Bern , Swiss National Science Foundation , Molecular Biology , Biomechanics Biophysics , Cell Biology , Molecular Biology , Molecular Physics , நேனத் தடை , தேசிய மையம் , பல்கலைக்கழகம் ஆஃப் பெர்ன் , சுவிஸ் தேசிய அறிவியல் அடித்தளம் , மூலக்கூறு உயிரியல் ,

Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021


Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021
According to the Johns Hopkins University, the COVID-19 pandemic has caused over 159 million confirmed cases and more than 3.31 million deaths as of today. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been in circulation globally for well over a year now. The virus has been mutating throughout this time, though at a slower pace when compared to the influenza virus and the human immunodeficiency virus (HIV). One SARS-CoV-2 variant of concern called the B.1.1.7 was found to be more infectious and fatal than other strains.
The emergence of this variant highlighted the uneven pace of mutation and selection of variants. New bioinformatics tools are the need of the hour to clarify this and confirm a dynamic evolution by tracking the mutation rates of the spike protein. It generally takes 1 – 6 months for current variants causing COVID-19 case peaks and deaths to sur ....

United States , Susha Cheriyedath , Johns Hopkins University , Global Initiative On Sharing All Influenza Data , Global Initiative , Sharing All Influenza Data , Estimated Spike Evolution , Gamma Regression , Coronavirus Disease Covid 19 , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , உலகளாவிய முயற்சி , உயிர் தகவலியல் ,

Stimulating environments boost the brain; now scientists have found the genes responsible


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Environmental enrichment with infrastructure, unfamiliar odors and tastes, and toys and puzzles is often used in zoos, laboratories, and farms to stimulate animals and increase their wellbeing. Stimulating environments are better for mental health and cognition because they boost the growth and function of neurons and their connections, the glia cells that support and feed neurons, and blood vessels within the brain. But what are the deeper molecular mechanisms that first set in motion these large changes in neurophysiology? That s the subject of a recent study in
Here, a multinational team of scientists used a large molecular toolbox to map, in unprecedented detail, how environmental enrichment leads to changes in the 3D organization of chromosomes in neurons and glia cells of the mouse brain, resulting in the activation or deactivation of a minority of genes within the genome. They show that genes which in humans are important for cognitive mental health ar ....

Comunidad Autonoma De Cataluna , Sergio Espeso Gil , Genomic Regulation , Cell Biology , Molecular Biology , Zoology Veterinary Science , Pets Ethology , Medicine Health , காமுனிடட தன்னாட்சி டி கடலுள் , செல் உயிரியல் ,