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The mechanism by which the LNC00115/miR-7/ERK axis promotes cisplatin resistance provides a new strategy for combating cisplatin resistance in ovarian cancer

7,8 and organ protection from ischemia/reperfusion injury. 9,10 Newly synthesized transition metal carbonyl-compounds, CO release molecules (CORMs), are effective in regulating CO release in vivo and in vitro in appropriate circumstances. 11 These CO releasing molecules can therefore be used as the new carrier to provide exogenous CO. CORM-3 [tricarbonylchloro (glycinato) ruthenium (II)] is completely soluble in water with fast release of CO when dissolved in a physiological solution. By releasing CO, CORMs also induce an anti-inflammatory effect. Our previous study showed that CORM-2 reduced...

Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH. Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O 2) exposure for 3 weeks. FDCA (15, 45, or 135 mg/kg i.g. daily) or the positive control, bosentan (100 mg/kg i.g....

13–15 Calycosin is a fat-soluble component in the dried root of Astragalus membranaceus, which are organic compounds widely found in nature. Calycosin exerts various anti-tumor activities in vitro and in vivo, 16–18 but its mechanism of action in human GC cells is not clear. In this study, we evaluated the effects of calycosin on apoptosis, the cell cycle, and migration of GC cells under ROS regulation. In addition, we also determined the roles of MAPK/STAT3/NF-κB pathways in these processes. Materials and Methods Cell Lines and Cell Culture Twelve types of GC cells (AGS, KATO-3, MKN-28...

3 1College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, People’s Republic of China; 2The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, People’s Republic of China; 3Mengchao Med-X Center, Fuzhou University, Fuzhou, 350025, People’s Republic of China; 4Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362001, People’s Republic of China Correspondence: Gaoxiong Wang Departmen...