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Cell Therapy Manufacturing: Time to Move Fast

Cell Therapy Manufacturing: Time to Move Fast
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Germany , Japan , Sweden , Yokohama , Kanagawa , Philadelphia , Pennsylvania , United-states , Swedish , Schaefer-jaramillo , Philip-schaefer-jaramillo , Matthew-hewitt

Anchor Capital Advisors LLC Reduces Position in Charles River Laboratories International, Inc. (NYSE:CRL)

Anchor Capital Advisors LLC Reduces Position in Charles River Laboratories International, Inc. (NYSE:CRL)
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United-states , Canada , Asia-pacific , Shannonm-parisotto , Meritage-group , Capital-advisors , Jpmorgan-chase-co , Quarter-for-charles-river-laboratories-international , Charles-river-laboratories-international-profile , Manufacturing-solutions , Charles-river-laboratories-international-inc , Insider-activity-at-charles-river-laboratories-international

Drug-Discovery Services Market Outlook, Size, Share & Forecast 2023 to 2033

Drug Discovery Services Market by Process (Target Selection, Target Validation, Hit-to-Lead Identification, Lead Optimization), by Type, by Drug Type, by Therapeutic Area, by Company Type, and Region - Global Trends, Market Share, and Forecast to 202

China , India , Israel , Canada , Belgium , France , Brazil , South-korea , Turkey , Japan , Poland , Egypt

New York State Common Retirement Fund Sells 5,565 Shares of Charles River Laboratories International, Inc. (NYSE:CRL)

New York State Common Retirement Fund reduced its holdings in Charles River Laboratories International, Inc. (NYSE:CRL – Free Report) by 4.1% during the fourth quarter, according to its most recent 13F filing with the Securities & Exchange Commission. The fund owned 131,078 shares of the medical research company’s stock after selling 5,565 shares during the […]

New-york , United-states , Canada , Williamd-barbo , Robertw-baird , Asia-pacific , Provence-wealth-management-group , York-state-common-retirement-fund , Venturi-wealth-management , Charles-river-laboratories-international-inc , Securities-exchange-commission , Quarter-for-charles-river-laboratories-international

FibroBiologics Plans to Collaborate with Charles River to Manufacture Fibroblast-based Spheroids

Next-generation cell therapies to target chronic diseasesHOUSTON, April 25, 2024 -- FibroBiologics, Inc., and Charles River Laboratories , a highly respected, global provider of drug discovery,...

Houston , Texas , United-states , Pete-oheeron , Nic-johnson , Liz-phillips , Nasdaq , Fibrobiologics-inc , Charles-river-laboratories , Charles-river , Chief-executive-officer , Private-securities-litigation-reform-act

Biomarkers Market Worth $93.8 billion | MarketsandMarkets

Biomarkers Market Worth $93.8 billion | MarketsandMarkets
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Switzerland , Netherlands , Germany , Canada , India , Chicago , Illinois , United-states , Northbrook , United-kingdom , France , Japan

Biomarkers Market Worth $93.8 billion | MarketsandMarkets™

/PRNewswire/ -- Biomarkers Market in terms of revenue was estimated to be worth $57.7 billion in 2024 and is poised to reach $93.8 billion by 2029, growing at...

Canada , India , Switzerland , Germany , Netherlands , United-states , Japan , United-kingdom , France , America , Aashish-mehra , Asia-pacific

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions1. TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impaired interneuron migration, activity-dependent dendrite retraction and an unanticipated persistent expression of exon 8A2–6. We reasoned that switching CACNA1C exon utilization from 8A to 8 would represent a potential therapeutic strategy. Here we developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells both in vitro and, following transplantation, in vivo. We discovered that the ASO-mediated switch from exon 8A to 8 robustly rescued defects in patient-derived cortical organoids and migration in forebrain assembloids. Leveraging a transplantation platform previously developed7, we found that a single intrathecal ASO administration rescued calcium changes and in vivo dendrite retraction of patient neurons, suggesting that suppression of CACNA1C exon 8A expression is a potential treatment for TS1. Broadly, these experiments illustrate how a multilevel, in vivo and in vitro stem cell model-based approach can identify strategies to reverse disease-relevant neural pathophysiology. Antisense oligonucleotides effectively decrease the inclusion of exon 8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons.

Fiji , Leica-stellaris , Teledyne-lumenera , Mount-polysciences , Leica-microsystems , Takara-bio , Beckman-coulter , Perkinelmer , International-electric-company , Fisher-scientific , Stanford-university , Bruker-corp

Platform integrates formulation development and on-demand GMP manufacturing

At CPhI North America, Quotient Sciences is looking forward to reconnecting with its customers and giving them a preview of how we are looking to expand Translational Pharmaceutics further within the US.

Pennsylvania , United-states , United-kingdom , Nottingham , Philadelphia , Ma-cdmos-cros , Pennsylvania-convention-center , Quotient-sciences , Charles-river-laboratories , Charles-river , Translational-pharmaceutics

Stem Cells Market Growth Trends Analysis and Dynamic Demand,

Stem Cells Market Growth Trends Analysis and Dynamic Demand,
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Cordlife-group-ltd , Bioreliance-corporation , Cell-international-inc , Global-cell-banking-outsourcing , Charles-river-laboratories , Cryo-cell-international-inc , Sartorious-stedim-biotech-group , Scientific-laboratories-munich-gmbh ,