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The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but nonmammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands develop at their adherens junctions. We hypothesized that the reinforced junctions were limiting regenerative responses of mammalian SCs by impeding changes in cell shape and epithelial tension. Using micropipette aspiration and atomic force microscopy, we measured mechanical properties of utricles fro...

Vaccines are essential to create a more resilient economic growth model. Ending the COVID-19 pandemic requires a more coordinated, effective, and equitable distribution of vaccines across the countries. Therefore, governments are in a race to increase the vaccination rates of the population. Given this backdrop, this paper focuses on the daily vaccinations per million data from March 1, 2021, to October 15, 2021, in 37 Organisation for Economic Co-operation and Development (OECD) countries and examines the stochastic properties of the vaccination rates. The results indicate a significant conve...

Motivated by the Covid-19 pandemic, most students of higher education institutions in Portugal experienced online learning from March 2020 to July 2020. Based on the answers by students to a set of two open questions included in a questionnaire, this paper aims to identify the positive (strengths) and negative (weaknesses) aspects of online learning during this period, which is also known as emergency remote teaching. 2,107 valid answers were gathered. Issues related to comfort and time management were the topics most frequently mentioned by students as strengths, particularly for those who ar...

Increasing rates of physical inactivity and sedentary behaviours among children and youth are important determinants of chronic disease. Supporting children’s participation in organized physical activities like sports has been promoted as a public health strategy to increase physical activity. Evidence shows that successful interventions are family-focused although research on how parental eating and physical activity behaviours influence children’s behaviours is deficient. In this commentary, we argue that interventions to counter physical inactivity and sedentary behaviours should includ...

The Sars-Cov2 health emergency has demonstrated the need for developing structured telemedicine systems to protect citizens from the spread of the virus. Thereby, their importance and the nessecity to tailor their diffusion at large scale for providing services both at a distance and in time has been shown. For these reasons, the European Union advocates the digital transition of health systems for the next five years. The main aim of this work is to revisit the telemedicine research projects financed by European Community during the period 2000-2020 with particular respect to the results deri...