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Two new genes linked to Alzheimer's disease discovered

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IMAGE: A schematic overview of the study design. AD = Alzheimer s disease; ADNI = Alzheimer s disease Neuroimaging Initiative; ADSP = Alzheimer s disease Sequencing Project; cis-GReX = cis-genetically regulated expression; FOCUS =.
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Credit: Liu N, et al., 2021, PLOS Genetics
A research team led by Chunshui Yu and Mulin Jun Li of Tianjin Medical University has discovered two new genes potentially involved in Alzheimer s disease. They identified them by exploring which genes were turned on and off in the hippocampus of people who suffered from the disease. The team s new findings are published February 25th in
PLOS Genetics.
Alzheimer s disease is a neurodegenerative disorder that involves worsening dementia and the formation of protein plaques and tangles in the brain. The hippocampus, part of the brain involved in memory, is one of the first regions to sustain damage. To better understand which genes contribute to the progres ....

Mulin Jun Li , Chunshui Yu , National Natural Science Foundation Of China , National Key Research , Tianjin Key Technology Rd Program , Tianjin Medical University , Development Program Of China , Development Program , National Natural Science Foundation , Medicine Health , Alzheimers Disease , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , தேசிய விசை ஆராய்ச்சி , வளர்ச்சி ப்ரோக்ர்யாம் ஆஃப் சீனா , வளர்ச்சி ப்ரோக்ர்யாம் , தேசிய இயற்கை அறிவியல் அடித்தளம் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் ,

Studies from Northeast Electric Power University Describe New Findings in Industrial Informatics (Stochastic Optimal Energy Management and Pricing for Load Serving Entity With Aggregated Tcls of Smart Buildings: a Stackelberg Game Approach)

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Information Technology Daily
2021 FEB 25 (NewsRx) By a News Reporter-Staff News Editor at Information Technology Daily Data detailed on Information Technology - Industrial Informatics have been presented. According to news reporting originating from Jilin, People’s Republic of China, by NewsRx correspondents, research stated, “With the development of demand-side management in the smart grid, load-serving entity (LSE) plays a more important role for consumers, which purchases energy from the electricity market and sells it to consumers. Moreover, aggregated thermostatically controlled loads (TCLs) in smart buildings can provide additional demand response capacities and require efficient energy management methods.”
Funders for this research include National Natural Science Foundation of China (NSFC), National Key Research and Development Program of China. ....

United States , Rufeng Zhang , Houhe Chen , Xue Li , Guoqing Li , National Natural Science Foundation Of China , Electrical Electronics Engineers Inc , Development Program Of China , Institute Of Electrical , Electronics Engineers , Stochastic Optimal Energy Management , Power University , National Key Research , Information Technology , News Reporter Staff Editor , National Natural Science Foundation , Development Program , Northeast Electric Power University , Load Serving Entity With Aggregated Tcls , Smart Buildings , Stackelberg Game , Industrial Informatics , Ieee Inst Electrical Electronics Engineers Inc , Electrical Engineering , ஒன்றுபட்டது மாநிலங்களில் , கிஷுே லி ,

Megadroughts in arid central Asia delayed the cultural exchange along the proto-Silk Road

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IMAGE: Historical Silk Road trade routes are illustrated in red, and the white star marks the studied cave in Central Asia
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Credit: @Science China Press
The Silk Road was the most elaborate network of trade routes in the ancient world, linking ancient populations in East Asia to those in southwest Asia, via Central Asia. These trade routes fostered the spread of ideas, religions, and technologies over the past 2,000 years. Before the establishment of organized exchange, starting around the time of the Chinese Han Dynasty (2,223 years ago), a process of trans-Eurasian exchange was already underway through the river valleys and oases of Central Asia. The establishment of populations in the oases of the Taklimakan Desert in Xinjiang, China, was a major factor facilitating this trans-Eurasian exchange. However, archaeological evidence for human occupation in these arid regions as well as long-distance diffusion of cultural material is largel ....

United States , United Kingdom , Nei Mongol , Hai Xu , Rustam Orozbaev , Robert Spengler , John Dodson , Ruiliang Liu , R Lawrence Edwards , Guanghui Dong , Yanjun Cai , Zhaiming Li , Fahu Chen , Jianhui Chen , National Key Research , University Of Wollongong , Institute Of Earth Environment , Chinese Academy Of Sciences , Development Program Of China , Lanzhou University , Silk Road , East Asia , Chinese Han Dynasty , Taklimakan Desert , Arid Central Asia , Central Asia ,

Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study

Research Article
Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study
Pan Zhuang,
Roles
Formal analysis,
Investigation,
Methodology,
Software,
Writing – original draft,
Writing – review & editing
Affiliations
National Engineering Laboratory of Intelligent Food Technology and Equipment, Fuli Institute of Food Science, Zhejiang University, Hangzhou, Zhejiang, China,
Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang, China,
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Fei Wu,
Roles ....

United States , Carson City , Rollins School , North Carolina , New Brunswick , New Jersey , Emory University , Georgia Center , New Orleans , Louisiana State University Health Sciences Center , Lindam Liao , Sigurd Hermansen , International Classification Of Diseases , National Cancer Institute , National Death Index , Division Of Public Health Services , Division Of Health Statistics , Department Of Epidemiology , Nevada Department Of Health , Behavioral Health , Division Of Public , Health Study , Pennsylvania Department Of Health , Arizona Department Of Health Services , Development Program Of China , Food Intakes ,

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis

In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.
Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, gluco ....

Jing Li , United Kingdom , Xiang Zhang , Junfeng Zhang , Antonio Vidal Puig , Dameng Li , Eunyoung Lee , Shibei Wang , Chen Yu Zhang , Xiaohong Jiang , Yuchen Liu , Xin Dai , Mingliang Zhang , Yujing Zhang , Weiping Jia , Century Excellent Talents In University , National Basic Research Program Of China , Institute Of Life Sciences , Key Laboratory Of Pharmaceutical Biotechnology , National Science Fund For Distinguished Young Scholars , University Of Cambridge , Program No , Drum Tower Hospital Center , Research Funds For The Central Universities , Natural Science Foundation Of Jiangsu Province , Ministry Of Education ,