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Amino acids signaling controls whole-body glucose homeostasis, study shows

Amino acids signaling controls whole-body glucose homeostasis, study shows
Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells. Amino acids have also recently been recognized as chemical signals that control cell growth and metabolism. Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism's genes is made inoperative, known as genetic knockout. Steven Zheng, PhD, chief of Cancer Pharmacology and researcher at Rutgers Cancer Institute is senior author of the work and shares more about the findings published in the March 16 online edition of

United-states , American , Steven-zheng , Emily-henderson , Centers-for-disease , Rutgers-cancer-institute-of-new-jersey , Rutgers-cancer-institute , New-jersey , Cancer-pharmacology , Disease-control , Diabetes , Amino-acid

Eight hallmarks of environmental exposures that contribute to disease

Eight hallmarks of environmental exposures that contribute to disease
A new review of existing evidence proposes eight hallmarks of environmental exposures that chart the biological pathways through which pollutants contribute to disease: oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function.
The study by researchers at Columbia University Mailman School of Public Health, Ludwig Maximilian University, and Hasselt University is published in the journal
Cell.
Every day we learn more about how exposure to pollutants in air, water, soil, and food is harmful to human health. Less understood, however, are the specific biological pathways through which these chemicals inflict damage on our bodies. In this paper, we provide a framework to understand why complex mixtures of environmental exposures bring about serious illness even at relatively modest concentrations."

Andrea-baccarelli , Emily-henderson , Environmental-health-sciences-at-columbia-mailman-school , Columbia-university-mailman-school-of-public-health , Ludwig-maximilian-university , Hasselt-university , Columbia-university-mailman-school , Public-health , Environmental-health-sciences , Columbia-mailman , Air-pollution , Cell

Molecular imaging can predict response to novel metastatic breast cancer treatment

Molecular imaging can predict response to novel metastatic breast cancer treatment
Molecular imaging can successfully predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients who are resistant to hormonal therapy. According to research published in the February issue of the
Journal of Nuclear Medicine, positron emission tomography (PET) imaging using an imaging agent called 18F-fluoroestradiol can help to determine which patients could benefit from treatments that could spare them from unnecessary chemotherapy.
Nearly two-thirds of invasive breast cancers are ER-positive, and endocrine therapy is the mainstay of treatment for these tumors because of its favorable toxicity profile and efficacy. Should cancer progress in these patients, however, salvage endocrine therapy with molecularly targeted agents or chemotherapy can help.

Washington , United-states , Seattle , Hannahm-linden , Emily-henderson , Journal-of-nuclear-medicine , Seattle-cancer-care-alliance-in , Nuclear-medicine , Athena-distinguished-professor , Breast-medical-oncologist , Washington-fred-hutchison-cancer-research-center , Seattle-cancer-care-alliance

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization

Vitamin D deficiency associated with higher risk of COVID-19 hospitalization
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic, continues to spread worldwide.
In an enormous research effort, the global scientific community continues to try and identify the causes of a wide variation in disease manifestations and severity.
A new study published in the journal
Endocrinein January 2021 shows that low levels of vitamin D are associated with a higher risk of COVID-19 hospitalization.
Risk factors for severe COVID-19
Of the 97 million confirmed cases across the globe, over 2 million people have died. The unusual nature of this virus is that it causes severe or even critical illness in a significant minority of patients, while the vast majority escape with no, mild or moderate symptoms.

Yerevan , Armenia , Armenian , Liji-thomas , Kavun-halyna-shutterstock , Endocrinein-january , Kavun-halyna , Coronavirus-disease-covid-19 , Sars-cov-2 , Vitamin-d , Vitamind-deficiency

Study finds new evidence about the positive role of androgens in breast cancer treatment

Study finds new evidence about the positive role of androgens in breast cancer treatment
Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.
Published today in
Nature Medicine, the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the role of androgens - commonly thought of as male sex hormones but also found at lower levels in women - as a potential treatment for estrogen receptor positive breast cancer.
Watch a video explainer about the new study at - https:/

University-of-adelaide , South-australia , Australia , Adelaide , Chloe-marshall , Stephen-birrell , Theresa-hickey , Wayne-tilley , Emily-henderson , Dame-roma-mitchell-cancer-research-laboratories , Garvan-institute , Garvan-institute-of-medical-research

Welcome To IANS Live - INTERNATIONAL - Male sex hormones may help treat breast cancer: Study

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life. Abno

India , Sydney , New-south-wales , Australia , Twitter , India-private , News-service , All-rights , Breast , Receptor , Cancer

Welcome To IANS Live - LatestNews - Male sex hormones may help treat breast cancer: Study

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life. Abno

India , Sydney , New-south-wales , Australia , Twitter , India-private , News-service , All-rights , Breast , Receptor , Cancer

Policymakers are urged to include government negotiation to reduce insulin prices

Policymakers are urged to include government negotiation to reduce insulin prices
The Endocrine Society is calling on policymakers to include government negotiation as part of an overall strategy to reduce insulin prices in its updated position statement published today in
The Journal of Clinical Endocrinology & Metabolism.
More than 34 million Americans have diabetes, and another 88 million are at risk for developing the disease. The cost of insulin has nearly tripled in the past 15 years, and a lack of transparency in the drug supply chain has made it challenging to identify and address the causes of soaring costs.
Federal law currently prohibits Medicare, which accounts for a third of all drug spending, from negotiating directly with pharmaceutical companies over drug prices. Legislation empowering the government to negotiate lower insulin prices could save billions and provide more benefits to Medicare beneficiaries.

Washington , District-of-columbia , United-states , Americans , Charles-best , Carol-wysham , Emily-henderson , Rockwood-multicare-health-systems , Endocrine-society , Endocrine-society-position-statement , Clinical-endocrinology , Frederick-banting

Study shows how intestinal stem cells constantly renew and give rise to specialized cell types

Study shows how intestinal stem cells constantly renew and give rise to specialized cell types
The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide.
Targeting endocrine dysfunction at an early stage by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, however, a detailed understanding of the intestinal stem cell lineage hierarchy and the signals regulating the recruitment of the different intestinal cell types is critical.

Munich , Bayern , Germany , German , Heiko-lickert , Emily-henderson , Technical-university-of-munich , Diabetes-research , Institute-of-diabetes , German-center , Regeneration-research-at-helmholtz-zentrum , Regeneration-research

Detailed text transcripts for TV channel - FOXNEWS - 20190206:11:27:00

because i looked up to her and to be right next to her that was pretty amazing. ainsley: grace, have you quite a story the president talked about when you were 4 years old there you are waving to the crowd. you are famous now. the president was talking about when you were 4 years old you were raising money for saint jude to help other children and then you were diagnosed with cancer. tell us about your story. >> so, basically what happened was i was just drinking a lot of water and then like my mom told my doctor, but he said that it was like nothing. and then so, at least a year later so that happened in first grade and then in second grade my growth started to slow down. and that's when my -- that's when the pediatrician got suspicious because that doesn't usually happen. so then he send us to an endocrine who thought i had diabetes. she sent us for an mri and

Have-steve , Ainsley , Rob , Grace , Story , 4 , Lot , Children , Mo-ney , Cancer , Mom , Water