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DGAP-PVR: Epigenomics AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution


DGAP-PVR: Epigenomics AG: Release according to Article 40, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution
Acquisition/disposal of instruments
X
Other reason:
Notification is triggered due to the application of the Custody Exemption available under Sect. 36 Para. 3 No. 2 WpHG
3. Details of person subject to the notification obligation
Legal entity: Morgan Stanley
4. Names of shareholder(s)
holding directly 3% or more voting rights, if different from 3.
5. Date on which threshold was crossed or reached:
18 May 2021
(total of 7.a.)
(total of 7.b.1 + 7.b.2)
New
a. Voting rights attached to shares (Sec. 33, 34 WpHG)
ISIN
Type of instrument ....

United States , Morgan Stanley , Morgan Stanley Capital Management , Distribution Services , Morgan Stanley Domestic Holdings Inc , Notification Of Major Holdings , Morgan Stanley International , News Service , Financial Holdings , Morgan Stanley Co , Morgan Stanley International Holdings Inc , Rights Announcement , Voting Rights Announcement , Entity Identifier , Custody Exemption , Stanley Investments , United Kingdom , Stanley Capital Management , Stanley Domestic Holdings , Regulatory Announcements , Corporate News , ஒன்றுபட்டது மாநிலங்களில் , மோர்கன் ஸ்டான்லி , மோர்கன் ஸ்டான்லி மூலதனம் மேலாண்மை , விநியோகம் சேவைகள் , மோர்கன் ஸ்டான்லி உள்நாட்டு ஹோல்டிங்ஸ் இன்க் ,

A CRISPR on-off switch for genes controls expression without altering DNA


April 12, 2021 A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in
Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression.
The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene editing methods.
CRISPR-Cas9 uses guide RNA to chaperone the Cas9 nuclease to a particular site in the DNA and create a double-strand break. By adding a specially designed short sequence of DNA, scientists can introduce permanent genetic changes to the cell. This oligonucleotide is used as a template by the cell when repairing the double-strand break, incorporating the sequence into the cell s genome. However, this approach can cause unintended genetic changes. ....

United States , San Francisco , Luke Gilbert , Jonathan Weissman , University Of California , Jennifer Cook Chrysos Whitehead Institute For Biomedical Research , Massachusetts Institute Of Technology , Massachusetts Institute , Whitehead Institute , Crispr Cas9 , Gene Editing Tools , Guide Rna , Epigenetic Changes , Gene Silencing , Transcriptional Repressor Proteins , Transcriptional Activator Domains , Fusion Proteins , Cas9 Proteins , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , லூக் கில்பர்ட் , ஜொனாதன் வெயிஸ்மேன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , மாசசூசெட்ஸ் நிறுவனம் , வைட்ஹெட் நிறுவனம் ,

Worldwide Precision Medicine Industry to 2025 - Targeted Gene Therapy Presents Opportunities


Worldwide Precision Medicine Industry to 2025 - Targeted Gene Therapy Presents Opportunities
March 12, 2021 05:03 ET
| Source:
Research and Markets
Research and Markets
Dublin, IRELAND
ResearchAndMarkets.com s offering.
The Global Precision Medicine Market is estimated to be USD 53.5 Bn in 2020 and is expected to reach USD 92.2 Bn by 2025 growing at a CAGR of 11.5%.
The factors such as patient s involvement in personal healthcare, development of technologies such as sequencing technologies, increasing genetic diseases, the growing demand for targeted therapies, and integration of big data healthcare companies with pharma & biotech companies are driving the market growth. The increasing population and rising cancer cases in developing countries in the APAC region like India and China are the major factors propelling the growth of the precision medicine market. The current soaring prices of drug discov ....

United States , United Kingdom , Asia Pacific , Bristol Myers Squibb , Laura Wood , Almac Group Ltd , National Institute Of Health , Omnicell Inc , Bristol Myers Squibb Company , Precision Medicine Initiative , Pharma Biotech Companies , Astellas Pharma Inc , Pfizer Inc , Ion Semiconductor Sequencing , Healthcare It Big Data Companies , Porter Five Forces Analysis , Eli Lilly Company , Office Hours Call , Laboratory Corporation Of America Holdings , Research Methodology , Roche Holding Ag , Company Profiles , Bio Rad Laboratories Inc , E St Office Hours Call , Amgen Inc , Tool Companies ,

Basic cell health systems wear down in Huntington's disease, analysis shows | MIT News | Massachusetts Institute of Technology


Caption:
Researchers employed a software system called Geomic to integrate vast amounts of gene expression data from the brains of mice modeling Huntington s disease. By comparing multidimensional mathematical surfaces plotted from the data, they were able to gain new insights into how gene expression differs in the disease based on many dimensions such as time, cell type and the extent of mutation in the huntingtin gene.
Credits:
Image: Lucile Megret/Sorbonne Universite
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Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage from the disease pathology itself. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , Picower Institute For Learning And Memory , Huntington Amp 039s Disease ,