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Fluoroquinolones: clearer evidence and guidance on safety are needed

Guidance on drug safety from regulatory agencies must be sensibly communicated and based on strong, clear evidence

Doctors learn early in their careers about the central importance of communication in medicine. Discussion of the relative risks and benefits of various treatment options, while considering the wider evidence and an individual patient’s circumstances and views, is challenging. The same challenge applies to guidance delivered from central bodies: it must be sensibly communicated, clear, based on published evidence, and applicable to a wide range of individual situations.

However, when the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) posted a drug safety update on fluoroquinolones in January 2024, stating that with immediate effect systemic fluoroquinolones “must only be administered when no other antibiotics are appropriate for use,”1 many clinicians were blindsided. Some heard it on the national news before the official email notification arrived. There was no opportunity to prepare alternative prescribing guidelines or to offer any reassurance to patients, as the MHRA hadn’t shared the new evidence on fluoroquinolones that had motivated this drastic and sudden restriction.

Fluoroquinolones are known …

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New insights into understanding obesity: from measures to mechanisms

New insights into understanding obesity: from measures to mechanisms
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Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail

Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail
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Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail

Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail
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Paris Olympics: Fergus Hamilton goes from rowing on dam to Games | The Canberra Times

Paris Olympics: Fergus Hamilton goes from rowing on dam to Games | The Canberra Times
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Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail

Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail
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Paris Olympics: Fergus Hamilton goes from rowing on dam to Games | The Canberra Times

Paris Olympics: Fergus Hamilton goes from rowing on dam to Games | The Canberra Times
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Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail

Australian rower Fergus Hamilton's road to Paris Olympics | The Border Mail
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Genes That Helped Us Survive Black Death Continue to Influence Our Mortality Today

The Black Death that ravaged Eurasia and North Africa in the 14th century had a profound effect on our balance of genes, one that according to a new study is still deciding our fate today.

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Gene That Shielded Some Against Black Death May Be Helping, Harming People Today

WEDNESDAY, March 8, 2023 (HealthDay News) Some people may have a gene that helps protect them from respiratory diseases like COVID-19 and helped their ancestors fight the plague.

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