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Researchers in the United States have conducted a study demonstrating that a gene called CXCR6 (C-X-C Motif Chemokine Receptor 6) may play an important role in determining the severity of COVID-19.
When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.
Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs). An article published in the journal Cancer Research describes a new molecular mechanism that counteracts the immunosupressive action of these macrophag...
Researchers find a way to measure key characteristics of proteins that bind to RNA A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells--a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections. RNA--short for ribonucleic acid--carries genetic instructions within the body. RNA-binding proteins play an important role in the regulation of gene expression. Scientists already knew that the way these proteins function depends on their ...
Modified CRISPR/Cas9 complex targets specific histones Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle. Rice University researchers have achieved something of the sort with a new genome editing tool that targets the supporting players in a cell's nucleus that package DNA and aid gene expression. Their work opens the door to new therapies for cancer and other diseases. Rice bioengineer Isaac Hilton, postdoctoral researcher and lead author Jing Li and their colleagues programmed a modified CRISPR/Cas9 complex to target specific histones, ubiquito...