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Study shows how collective behavior of bacterial colonies may contribute to antibiotic resistance

Study shows how collective behavior of bacterial colonies may contribute to antibiotic resistance
The bacterial equivalent of a traffic jam causes multilayered biofilms to form in the presence of antibiotics, shows a study published today in
eLife.
The study reveals how the collective behavior of bacterial colonies may contribute to the emergence of antibiotic resistance. These insights could pave the way to new approaches for treating bacterial infections that help thwart the emergence of resistance.
Bacteria can acquire resistance to antibiotics through genetic mutations. But they can also defend themselves via collective behaviors such as joining together in a biofilm - a thin, slimy film made up of many bacteria that is less susceptible to antibiotics. ....

United Kingdom , Iago Grobas , Marco Polin , Emily Henderson , Munehiro Asally , Warwick Medical School , School Of Life Sciences , Mediterranean Institute For Advanced Studies , University Of Warwick , Department Of Physics , Study First Author , Phd Student , Associate Professor , Life Sciences , Mediterranean Institute , Advanced Studies , Antibiotic Resistance , Bacillus Subtilis , ஒன்றுபட்டது கிஂக்டம் , மார்கோ பொழிந் , எமிலி ஹென்டர்சன் , வார்விக் மருத்துவ பள்ளி , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , பல்கலைக்கழகம் ஆஃப் வார்விக் , துறை ஆஃப் இயற்பியல் , படிப்பு முதல் நூலாசிரியர் ,

Researchers identify a genetic defect that increases the risk of debilitating eye disease

Researchers identify a genetic defect that increases the risk of debilitating eye disease
A genetic defect could hold the key to preventing or delaying the onset of a debilitating eye disease that can lead to vision loss and blindness.
MacTel (macular telangiectasia type 2) affects one in 1,000 Australians. Symptoms include slow loss of vision, distorted vision and trouble reading. Because early signs of the disorder are subtle, it is difficult to diagnose.
Researchers have identified an additional seven regions in the human genome that increase the risk of developing the condition, including a rare DNA mutation in the PHGDH gene, which will help clinicians to better diagnose and treat it. ....

United States , United Kingdom , Melanie Bahlo , Brendan Ansell , Roberto Bonelli , Emily Henderson , Lowy Medical Research Institute , Communications Biology , Eye Hospital , Professor Bahlo , Eye Disease , Amino Acid , Blood Vessels , Medical Research , Vision Loss , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பிரெண்டன் முன்செல்ல , ரொபெர்டோ போனெல்லி , எமிலி ஹென்டர்சன் , தாழ்வான மருத்துவ ஆராய்ச்சி நிறுவனம் , தகவல்தொடர்புகள் உயிரியல் , கண் மருத்துவமனை , கண் நோய் , அமினோ அமிலம் , இரத்தம் நாளங்கள் ,

Amino acids signaling controls whole-body glucose homeostasis, study shows

Amino acids signaling controls whole-body glucose homeostasis, study shows
Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells. Amino acids have also recently been recognized as chemical signals that control cell growth and metabolism. Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism s genes is made inoperative, known as genetic knockout. Steven Zheng, PhD, chief of Cancer Pharmacology and researcher at Rutgers Cancer Institute is senior author of the work and shares more about the findings published in the March 16 online edition of ....

United States , Steven Zheng , Emily Henderson , Centers For Disease , Rutgers Cancer Institute Of New Jersey , Rutgers Cancer Institute , New Jersey , Cancer Pharmacology , Disease Control , Amino Acid , Medical School , Type 2 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , ஸ்டீவன் ஜெங் , எமிலி ஹென்டர்சன் , மையங்கள் க்கு நோய் , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் ஆஃப் புதியது ஜெர்சி , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் , புதியது ஜெர்சி , புற்றுநோய் மருந்தியல் , நோய் கட்டுப்பாடு , நீரிழிவு நோய் , அமினோ அமிலம் , மருத்துவ பள்ளி , வளர்சிதை மாற்றம் ,

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis
TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models. They found that TARM1 activated dendritic cells, and development of collagen-induced arthritis (CIA) was notably suppressed in TARM1-deficient mice and by treatment with TARM1-inhibitory soluble TARM1 proteins. This makes the protein a potential therapeutic target.
Autoimmune diseases are typically caused when the immune system, whose purpose is to deal with foreign threats to the body, incorrectly recognizes the body s own proteins and cells as threats and activates immune cells to attack them. In the case of rheumatoid arthritis, a well-known autoimmune disease, immune cells erroneously attack the body s own joint components and proteins, caus ....

Yoichiro Iwakura , Rikio Yabe , Shinobu Saijo , Emily Henderson , Nature Communications , Tokyo University Of Science , Chiba University , Professor Yoichiro Iwakura , Tokyo University , Autoimmune Disease , Immune Response , Immune System , Rheumatoid Arthritis , ஷினோபு சைஜோ , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , டோக்கியோ பல்கலைக்கழகம் ஆஃப் அறிவியல் , சிபா பல்கலைக்கழகம் , டோக்கியோ பல்கலைக்கழகம் , ஆட்டோ இம்யூன் நோய் , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு , முடக்கு கீல்வாதம் ,

New cancer immunotherapy uses engineered T cells to target a common genetic alteration

New cancer immunotherapy uses engineered T cells to target a common genetic alteration
Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that are missing one gene copy, called loss of heterozygosity (LOH), was developed by researchers at the Ludwig Center, Lustgarten Laboratory and the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center.
Genes have two alleles, or copies, with one copy inherited from each parent. Cancer-related genetic alterations commonly involve the loss of one of these gene copies. ....

Kenneth Kinzler , Shibin Zhou , Michael Hwang , Bert Vogelstein , Emily Henderson , Ludwig Center , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Proceedings Of The National Academy Sciences , Johns Hopkins University School Of Medicine , Lustgarten Laboratory , Kimmel Institute , Johns Hopkins Kimmel Cancer , National Academy , Johns Hopkins University School , Brian Mog , Immune Response , ஷிபின் ஜூ , மைக்கேல் ஹ்வ்யாஂக் , பெர்ட் வோகல்ஸ்டீன் , எமிலி ஹென்டர்சன் , லுட்விக் மையம் , ப்ளூம்பெர்க் கீம்மேல் நிறுவனம் க்கு புற்றுநோய் நோயெதிர்ப்பு சிகிச்சை , ஜான்ஸ் ஹாப்கின்ஸ் கீம்மேல் புற்றுநோய் மையம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , கீம்மேல் நிறுவனம் ,