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Welcome To IANS Live - SCIENCE AND TECHNOLOGY - Novel gene editor to correct disease-causing mutations

One in seventeen people in the world suffers from some type of genetic disorder. ....

India Private , News Service , C Tog Base Editor , All Rights , இந்தியா ப்ரைவேட் , செய்தி சேவை , அனைத்தும் உரிமைகள் ,

Research provides a new cornerstone of malaria's evolution with humans

Research provides a new cornerstone of malaria s evolution with humans
New bioarchaeological research shows malaria has threatened human communities for more than 7000 years, earlier than when the onset of farming was thought to have sparked its devastating arrival.
Lead author Dr Melandri Vlok from the Department of Anatomy, University of Otago, says this ground-breaking research, published today in
Scientific Reports, changes the entire understanding of the relationship humans have had with malaria, still one of the deadliest diseases in the world.
Until now we ve believed malaria became a global threat to humans when we turned to farming, but our research shows in at least Southeast Asia this disease was a threat to human groups well before that. ....

Republic Of , Justyna Miszkiewicz , Melandri Vlok , Marc Oxenham , Hallie Buckley , Emily Henderson , Vietnam Institute Of Archaeology , Australian National University , World Health Organization , University Of Aberdeen , James Cook University , Department Of Anatomy , Sapporo Medical University , University Of Otago , Scientific Reports , Southeast Asia , Professor Marc Oxenham , Vietnam Institute , Sapporo Medical , Professor Hallie Buckley , குடியரசு ஆஃப் , ஹாலி பக்லி , எமிலி ஹென்டர்சன் , வியட்நாம் நிறுவனம் ஆஃப் தொல்பொருள் , ஆஸ்திரேலிய தேசிய பல்கலைக்கழகம் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் ,

Researchers discover new molecular target that could treat idiopathic pulmonary fibrosis

Researchers discover new molecular target that could treat idiopathic pulmonary fibrosis
Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially treat the deadly, aging-related lung disease idiopathic pulmonary fibrosis (IPF). The study, which will be published March 10 in the
Journal of Experimental Medicine (
JEM), suggests that targeting a protein called MDM4 could prevent respiratory failure by initiating a genetic program that removes scar tissue from the lungs.
IPF is characterized by the accumulation of scar tissue that stiffens the lungs and makes it difficult for patients to breathe and get sufficient oxygen into their blood. Though the causes of IPF remain unclear, age is a significant risk factor: the disease is estimated to affect 1 in 200 US adults over the age of 70. ....

Emily Henderson , Department Of Medicine , University Of Alabama At Birmingham , Experimental Medicine , Pulmonary Fibrosis , Idiopathic Pulmonary Fibrosis , Lung Disease , எமிலி ஹென்டர்சன் , துறை ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம் , சோதனை மருந்து , நுரையீரல் ஃபைப்ரோஸிஸ் , நுரையீரல் நோய் ,

NTU scientists design new compound that could help reduce overactive immune response

NTU scientists design new compound that could help reduce overactive immune response
When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure itself, which may prove fatal in some cases.
Now, scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a compound that could help to reduce this overactivation without impairing the body s entire immune response.
An overactive immune system leads to many autoimmune disorders - when the immune system mistakenly attacks healthy tissues - such as rheumatoid arthritis and type 1 diabetes. More recently, it has also been linked to severe COVID-19 infections, in which immune-system signalling proteins ramp up to dangerous levels, leading to damage to the body s own cells. ....

United States , Phan Anh Tuan , Emily Henderson , American Association Of Immunologists , Nanyang Technological University , Mathematical Sciences , Institute Of Structural Biology , University Of Edinburgh , Professor Phan Anh Tuan , Structural Biology , Lim Kah Wai , United Kingdom Led , American Association , Immune Response , Immune System , Rheumatoid Arthritis , Type 1 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , ஃப்யாந் அந்த் ட்யூவாந் , எமிலி ஹென்டர்சன் , அமெரிக்கன் சங்கம் ஆஃப் நோயெதிர்ப்பு நிபுணர்கள் , கணித அறிவியல் , நிறுவனம் ஆஃப் கட்டமைப்பு உயிரியல் , பல்கலைக்கழகம் ஆஃப் எடின்பர்க் , ப்ரொஃபெஸர் ஃப்யாந் அந்த் ட்யூவாந் , கட்டமைப்பு உயிரியல் ,

Whole genome sequencing may guide blood cancer treatment

Whole genome sequencing may guide blood cancer treatment
For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes.
Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades.
Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addition, results can be returned to patients in just a few days, making whole genome sequencing a potentially viable approach for determining the best treatment regimen for a parti ....

Ericj Duncavage , Mollyc Schroeder , Peter Campbell , Davidh Spencer , Emily Henderson , Mcdonnell Genome Institute , Washington University , Siteman Cancer Center At Barnes , Wellcome Sanger Institute In Cambridge , Washington University School Of Medicine , Siteman Cancer Center , Department Of Pathology Immunology , Washington University School , New England Journal , Study Senior Author , Assistant Professor , Medical Director , Clinical Sequencing Facility , Mcdonnell Genome , Barnes Jewish Hospital , Siteman Cancer , Wellcome Sanger Institute , Blood Cancer , Whole Genome Sequencing , Acute Myeloid Leukemia , Bone Marrow ,