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RNA editing events influence gene expression and phenotypic manifestation

RNA editing events influence gene expression and phenotypic manifestation
Combining computational mining of big data with experimental testing in the lab, researchers at Children s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression.
In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a single nucleotide change by RNA editing can have large downstream effects. The findings were published today in
Genome Biology.
Millions of A-to-I RNA editing sites have been identified across the human transcriptome, but the functions of most RNA editing events are unknown. Understanding how RNA editing affects gene expression and phenotype could help us unravel the genetic basis to many human conditions. ....

United States , Emily Henderson , Study Senior Author , Genomic Medicine , Tissue Expression , Gene Expression , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , படிப்பு மூத்தவர் நூலாசிரியர் , திசு வெளிப்பாடு , கீந் வெளிப்பாடு ,

Humans Have Surprising Similarities to Strange Creatures From 550 Million Years Ago

Humans Have Surprising Similarities to Strange Creatures From 550 Million Years Ago
9 MARCH 2021
From what little we know of them, they seem so different. Mysterious creatures that lived in the ocean half a billion years ago – headless, limbless things, seemingly alien to us in all respects.

Except they weren t, new research suggests. In fact, the Ediacaran biota – a collection of ancient oceanic life-forms that dwelled on Earth between 570 to 539 million years ago – would have shared a number of genetic similarities with modern metazoans (multicellular animals) including humans, scientists say.
Not that the resemblances border on the uncanny, or anything.
None of them had heads or skeletons, explains palaeobiologist Mary Droser from the University of California, Riverside. ....

United States , Scott Evans , Mary Droser , University Of California , Smithsonian National Museum Of Natural History , President Obama , Smithsonian National Museum , Natural History , Amp Quot , ஒன்றுபட்டது மாநிலங்களில் , ஸ்காட் எவன்ஸ் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , ஸ்மித்சோனியன் தேசிய அருங்காட்சியகம் ஆஃப் இயற்கை வரலாறு , ப்ரெஸிடெஂட் ஒபாமா , ஸ்மித்சோனியன் தேசிய அருங்காட்சியகம் , இயற்கை வரலாறு ,

Greater cross-neutralization against UK SARS-CoV-2 variant in vaccinated individuals with prior infection

A team of researchers in Spain has observed that, of those who have been vaccinated against SARS-CoV-2, higher titers of neutralizing antibodies for the B.1.1.7 variant (originating in the UK) were present in those who had previously been infected with the virus. ....

United Kingdom , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

A genetic variant of TMPRSS2 may confer protection against severe COVID-19

A genetic variant of TMPRSS2 may confer protection against severe COVID-19
Among a large sample of coronavirus disease 2019 (COVID-19) patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, can have a diverse range of effects on people. Some people develop no symptoms; some have mild fever, sore throat, among other symptoms; whereas in others, the infection becomes more severe and often fatal.
Apart from age, gender, and other diseases, genetics has also emerged as another determinant of COVID-19 severity. Genetic variants involved in the regulation of interferon immunity are associated with severe COVID-19. Genome-wide association studies (GWAS) have identified several genetic groups associated with severe COVID-19. ....

Lakshmi Supriya , Phd Mar , Billion Photos , East Asian , South Asian , South Asians , Coronavirus Disease Covid 19 , Sars Cov 2 , Amino Acid , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Sore Throat , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் மார் , பில்லியன் புகைப்படங்கள் , கிழக்கு ஆசிய , தெற்கு ஆசிய , தெற்கு ஆசியர்கள் , அமினோ அமிலம் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , புண் தொண்டை , ஸ்பைக் ப்ரோடீந் ,

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans
In a recent report made available on
bioRxiv preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.
st century (after SARS-CoV and MERS-CoV viruses).
And while mass vaccination activities against COVID-19 are currently underway on a global level, we are still not yet sure how this pandemic (and its causative virus) will end. In other words, highly touted concepts of herd immunity and viral eradication are increasingly seen as unrealistic when prevalence, genetic diversity and pervasive animal reservoirs are taken into account. ....

Lukasz Rabalski , University Of Gdansk , National Veterinary Research Institute , Intercollegiate Faculty , Medical University , Northern Poland , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , தேசிய கால்நடை ஆராய்ச்சி நிறுவனம் , இண்டெற்கொள்ளேகியதே ஆசிரிய , மருத்துவ பல்கலைக்கழகம் , வடக்கு போல்யாஂட் , சர்வதேச பரவல் , கொரோனா வைரஸ் , மேற்ச் கோவ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,