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Inherited or transmitted gut microbes affect skeletal development in animals


Inherited or transmitted gut microbes affect skeletal development in animals
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals bone mass, says a new study published today in
eLife.
The findings suggest that treatments which alter the gut microbiome could help improve bone structure or treat conditions that weaken bones, such as osteoporosis.
Genetics account for most of the variability in human bone density, but non-genetic factors such as gut microbes may also play a role. We wanted to investigate the influence of the microbiome on skeletal growth and bone mass development. ....

United States , Emory University , Abdul Malik Tyagi , Roberto Pacifici , Emily Henderson , Lipids At Emory Microbiome Research Center , Division Of Endocrinology , Malik Tyagi , Lead Author , Assistant Staff Scientist , Emory Microbiome Research Center , Garland Herndon Professor , ஒன்றுபட்டது மாநிலங்களில் , உணர்ச்சி பல்கலைக்கழகம் , அப்துல் மாலிக் தியாகி , ரொபெர்டோ பசிபிசி , எமிலி ஹென்டர்சன் , பிரிவு ஆஃப் உட்சுரப்பியல் , மாலிக் தியாகி , வழி நடத்து நூலாசிரியர் , உதவியாளர் ஊழியர்கள் விஞ்ஞானி , மாலை ஹெர்ன்டன் ப்ரொஃபெஸர் , வளர்சிதை மாற்றம் ,

Biologists reveal unusual structure of coronavirus protein linked to immune evasion


Biologists reveal unusual structure of coronavirus protein linked to immune evasion
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells. The structural map – which is now published in the journal PNAS, but has been open-access for the scientific community since August – has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body.
Using X-ray crystallography, we built an atomic model of ORF8, and it highlighted two unique regions: one that is only present in SARS-CoV-2 and its immediate bat ancestor, and one that is absent from any other coronavirus. These regions stabilize the protein – which is a secreted protein, not bound to the membrane like the viru ....

United States , Marc Allaire , James Hurley , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Bioimaging Division , Berkeley Lab Molecular Biophysics , Lead Author , Former Faculty Scientist , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Corona Virus , Amino Acid , Sars Cov 2 , X Ray , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , எமிலி ஹென்டர்சன் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,