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Researchers map genetic changes that may have facilitated SARS-CoV-2's jump from bats to humans

Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis. ....

United States , United Kingdom , Saudi Arabia , Stephen Graham , Angela Betsaidab Laguipo , University Of Cambridge , University Of Cambridge Department Pathology , Pirbright Institute , Temple University , D Weblogo University Of California , Angela Betsaida , Wuhan City , Image Credit , Middle East Respiratory Syndrome , Sars Cov 2 , Amino Acid , Angiotensin Converting Enzyme 2 , Corona Virus , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சவுதி அரேபியா , ஸ்டீபன் கிரஹாம் ,

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology
Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives. With this progress it has become apparent that many non-skeletal rare diseases have an impact on bone mass, bone quality and/or bone metabolism, with potentially severe repercussions for quality of life in adults.
The new paper Bone fragility in patients affected by congenital diseases non skeletal in origin , published in
Orphanet Journal of Rare Diseases by the International Osteoporosis Foundation (IOF) Skeletal Rare Diseases Working Group (SRDWG), provides a first taxonomic classification of selected non-skeletal rare congenital disorders with an impact on bone physiology on the basis of phenotypes. The diseases have been described according to the systemic disease; genetic defect; pathophysio ....

Maria Luisa Brandi , Nicholas Harvey , Emily Henderson , Skeletal Rare Diseases Working Group , International Osteoporosis Foundation , Skeletal Rare Diseases Academy , Committee Of Scientific Advisors , Skeletal Rare Disease Academy , Orphanet Journal , Rare Diseases , Rare Disease , Luisa Brandi , Scientific Advisors , Rare Disease Academy , Rare Diseases Academy , மரியா லூயிசா பிராந்தி , நிக்கோலஸ் ஹார்வி , எமிலி ஹென்டர்சன் , எலும்பு ரேர் நோய்கள் வேலை குழு , சர்வதேச அஸ்டீயாப்ரோஸிஸ் அடித்தளம் , எலும்பு ரேர் நோய்கள் கலைக்கழகம் , எலும்பு ரேர் நோய் கலைக்கழகம் , ரேர் நோய்கள் , ரேர் நோய் , லூயிசா பிராந்தி , ரேர் நோய் கலைக்கழகம் ,

Study: 20% of glioblastomas are fueled by overactive mitochondria

Study: 20% of glioblastomas are fueled by overactive mitochondria
A new study has found that up to 20% of glioblastomas an aggressive brain cancer are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials.
Mitochondria are responsible for creating the energy that fuels all cells. Though they are usually less efficient at producing energy in cancer, tumor cells in this newly identified type of glioblastoma rely on the extra energy provided by overactive mitochondria to survive.
The study, by cancer scientists at Columbia University s Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, was published online Jan. 11 in ....

Anna Lasorella , Antonio Iavarone , Emily Henderson , Columbia University Vagelos College Of Physicians , Columbia University Medical Center , Herbert Irving Comprehensive Cancer Center , Columbia Institute For Cancer Genetics , Columbia University , Vagelos College , Columbia University Medical , Brain Cancer , Public Health , எமிலி ஹென்டர்சன் , கொலம்பியா பல்கலைக்கழகம் மருத்துவ மையம் , ஹெர்பர்ட் இவிஂக் விரிவான புற்றுநோய் மையம் , கொலம்பியா நிறுவனம் க்கு புற்றுநோய் ஜெநெடிக்ஸ் , கொலம்பியா பல்கலைக்கழகம் , கொலம்பியா பல்கலைக்கழகம் மருத்துவ , மூளை புற்றுநோய் , குழந்தை மருத்துவம் , பொது ஆரோக்கியம் ,

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells
A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.
The structural map - which is now published in the journal
PNAS, but has been open-access for the scientific community since August - has laid the groundwork for new antiviral treatments tailored specifically to SARS-CoV-2, and enabled further investigations into how the newly emerged virus ravages the human body. ....

United States , Marc Allaire , James Hurley , Emily Henderson , Lawrence Berkeley National Laboratory Lab , Berkeley Lab Advanced Light Source , Berkeley Center , Bioimaging Division , Berkeley Lab Molecular Biophysics , Lead Author , Former Faculty Scientist , Lawrence Berkeley National Laboratory , Berkeley Lab , Structural Biology , Advanced Light Source , Molecular Biophysics , Integrated Bioimaging , Corona Virus , Amino Acid , Sars Cov 2 , X Ray , ஒன்றுபட்டது மாநிலங்களில் , மார்க் அல்லேர் , ஜேம்ஸ் ஹர்லி , எமிலி ஹென்டர்சன் , லாரன்ஸ் பெர்க்லி தேசிய ஆய்வகம் ஆய்வகம் ,

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2
A recent study conducted at the University of Malta Medical School, Malta, has revealed that a drop in the level of particulate matter 2.5 (PM2.5), which are airborne pollutant particles with a diameter of 2.5 micrometers, in the atmosphere due to lockdown is associated with the arrival of a newer variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has eventually displaced the original virus after lockdown. The new viral variant (D614G mutant) may be able to use other types of PM, including the one that originated from tobacco smoking, as a viral vector for transmission. The study is currently available on the ....

United Kingdom , New South Wales , Sanchari Sinha Dutta , University Of Malta Medical School , Malta Medical School , Viral Counts , Could Viral Natural Selection , Airborne Pollutant , Image Credit , Air Quality Index , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Medical School , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Viral Vector , ஒன்றுபட்டது கிஂக்டம் , புதியது தெற்கு வேல்ஸ் , சஞ்சரி சீன்ஹா தத்தா , பல்கலைக்கழகம் ஆஃப் மால்டா மருத்துவ பள்ளி , மால்டா மருத்துவ பள்ளி , வைரஸ் எண்ணிக்கைகள் , முடியும் வைரஸ் இயற்கை தேர்வு , படம் கடன் , அேக தரம் குறியீட்டு ,