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Modified CRISPR/Cas9 complex targets specific histones

Modified CRISPR/Cas9 complex targets specific histones
Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle.
Rice University researchers have achieved something of the sort with a new genome editing tool that targets the supporting players in a cell s nucleus that package DNA and aid gene expression. Their work opens the door to new therapies for cancer and other diseases.
Rice bioengineer Isaac Hilton, postdoctoral researcher and lead author Jing Li and their colleagues programmed a modified CRISPR/Cas9 complex to target specific histones, ubiquitous epigenetic proteins that keep DNA in order, with pinpoint accuracy. ....

Isaac Hilton , Jing Li , Emily Henderson , Nature Communications , Rice University , Gene Expression , Genome Editing , ஐஸ்யாக் ஹில்டன் , ஜிங் லி , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , அரிசி பல்கலைக்கழகம் , கீந் வெளிப்பாடு , மரபணு திருத்துதல் ,

CRISPR genomic editing to obtain more productive and nutritive plant varieties

New study by the IBMCP of the UPV university facilitates the use of the CRISPR genomic editing technique on plants. ....

Francis Mojica , Emily Henderson , Polytechnic University Of Valencia , Institute Of Plant Molecular , Spanish National Research Council , Plant Molecular , Cellular Biology , Polytechnic University , Alicante Native Francis Mojica , Viral Vector , பிரான்சிஸ் மோஜிகா , எமிலி ஹென்டர்சன் , பாலிடெக்நிக் பல்கலைக்கழகம் ஆஃப் வலென்சியா , நிறுவனம் ஆஃப் ஆலை மூலக்கூறு , ஸ்பானிஷ் தேசிய ஆராய்ச்சி சபை , ஆலை மூலக்கூறு , செல்லுலார் உயிரியல் , பாலிடெக்நிக் பல்கலைக்கழகம் , அளிக்கண்டே பூர்வீகம் பிரான்சிஸ் மோஜிகா , வைரஸ் திசையன் ,

Furin cleavage SARS-CoV-2 spike deletions mostly suppressed within infected airway epithelium, says study

A team of researchers recently examined the SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , சர்வதேச பரவல் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Scientists identify genomic signatures of long-term survival in luminal breast cancer patients

Scientists identify genomic signatures of long-term survival in luminal breast cancer patients
Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analyzed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques.
Carried out by Lydia King during her studies in NUI Galway s MSc in Biomedical Genomics programme, the research has been published in the international journal
PLOS ONE.
Early detection by national screening programmes and timely treatment for patients diagnosed with luminal types of breast cancer have resulted in excellent prognoses with survival rates of over 80% within five years of treatment. The challenge of long-term survival however is not as well understood and studies have shown that more than half of all recurrences for luminal breast cancers take ....

United Kingdom , Emma Holian , Andrew Flaus , Lydia King , Emily Henderson , Cambridge University , Molecular Taxonomy Of Breast Cancer International Consortium , School Of Natural Sciences , Galway School Of Mathematics , Science Foundation Ireland , Biomedical Genomics , Molecular Taxonomy , Breast Cancer International Consortium , Natural Sciences , Aaron Golden Senior Author , Programme Director , Research Training , Genomics Data Science , Cancer Treatment , Breast Cancer , ஒன்றுபட்டது கிஂக்டம் , எம்மா ஹோலியன் , லிடியா கிங் , எமிலி ஹென்டர்சன் , கேம்பிரிட்ஜ் பல்கலைக்கழகம் , பள்ளி ஆஃப் இயற்கை அறிவியல் ,

New combination therapy proven to be highly effective in HBV infection model

New combination therapy proven to be highly effective in HBV infection model
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model.
The new therapeutic approach is based on shutting down the viral hepatitis B genome located in the nucleus of infected liver cells. Upon infection of the liver cell, the viral genome is transformed inside the nucleus into a closed circular DNA molecule. This deoxyribonucleic acid is a stable molecule known as covalently closed circular DNA (cccDNA) and serves as the template for the production of new virus ....

Nordrhein Westfalen , Maura Dandri , Emily Henderson , University Hospital Eppendorf , Infection Research , German Center , Hepatitis B , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , எமிலி ஹென்டர்சன் , தொற்று ஆராய்ச்சி , ஜெர்மன் மையம் , எதிர் மின்னணு ,