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Dante Labs achieves ISO 13485 certification for its Genomic Interpretation Software Immensa, leveraging an 18 month long clinical validation study of 500,000 samples

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Dante Labs, a world leader in genomic sequencing and data analysis, announced today that it received ISO 13485:2016 certification for its Immensa Genomic Interpretation Software as a medical device. The highly coveted industry certification involved a deep clinical validation study carried out by several teams at Dante Labs over an 18 month period. The accreditation was awarded by The British Standards Institution (BSI) Group.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210405005027/en/
Dante Labs Automatic Lab (Photo: Business Wire)
This is a great achievement for all of the team members at Dante Labs who worked very hard to implement a brand-new ISO-compliant quality system and develop the software, says Dante Labs CEO Andrea Riposati. The bioinformatics team ran a clinical validation study the size of a population genomics program. ....

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Discovering DNA methylation from bacteria and microbiome using nanopore technology

Discovering DNA methylation from bacteria and microbiome using nanopore technology
Journal name:
Nature Methods
Title of the article: Discovering multiple types of DNA methylation from individual bacteria and microbiome using nanopore sequencing
Corresponding author: Gang Fang, PhD
Bottom line:
Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others.
Bacterial methylomes contain three primary forms of DNA methylation: N6-methyladenine (6 mA), N4-methylcytosine (4mC) and 5-methylcytosine (5mC). The widely used bisulfite sequencing for DNA methylation mapping in mammalian genomes are not effective at resolving bacterial methylomes. Single molecule real-tim ....

Emily Henderson , Gang Fang , Mount Sinai , Dna Methylation , எமிலி ஹென்டர்சன் , கும்பல் ஃப்யாஂக் , ஏற்ற சினை ,

High expression of cell death genes may increase risk of early death from lung cancer

High expression of cell death genes may increase risk of early death from lung cancer
Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.
Also seemingly paradoxically, patients with high expression of this 21-gene cell death signature the researchers have identified, have indicators that their immune system is attacking the cancer, like higher levels of cytotoxic T cells, which typically kill cancer.
But they also have high levels of molecules that can suppress those T cells, helping transform them into dysfunctional, exhausted T cells, they report in the journal ....

United States , Ravindra Kolhe , Emily Henderson , Centers For Disease , National Cancer Institute , National Human Genome Research Institute , Drug Administration , Cancer Research Institute , College Of Georgia Department Pathology , Georgia Esoteric , Medical College , Georgia Department , Cancer Genome Atlas , National Human Genome Research , Disease Control , Cancer Research , Cell Death , Lung Cancer , Immune System , Pd L1 , ஒன்றுபட்டது மாநிலங்களில் , ரவின்ற கொள்ே , எமிலி ஹென்டர்சன் , மையங்கள் க்கு நோய் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய மனிதன் மரபணு ஆராய்ச்சி நிறுவனம் ,

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa

Researchers identify a novel SARS-CoV-2 variant (A.VOI.V2) in southern Africa
A team of international scientists has recently explored the transmission dynamics of currently circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a southern African country. By analyzing the genomic sequences of these variants, they have identified a novel SARS-CoV-2 variant with multiple spike mutations. They have temporarily designated the variant A.VOI.V2. A detailed description of the genomic surveillance they carried out is currently available on the
Background
Since its emergence in December 2019, SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), has undergone more than 12,000 mutations. The majority of these mutations are found in the viral spike protein, which is a glycoprotein on the viral envelope required for establishing SARS-CoV-2 infection. Because of robust immunogenicity, the spike protein is considered to be the ....

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First-of-its-kind study identifies 13 new Alzheimer's disease genes

First-of-its-kind study identifies 13 new Alzheimer’s disease genes
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer s disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and neuroplasticity, or the ability of neurons to reorganize the brain s neural network. These discoveries could help guide development of new therapies for this devastating neurological condition.
Researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center report these findings in ....

United States , Rudolph Tanzi , Dmitry Prokopenko , Emily Henderson , Research Unit , Beth Israel Deaconess Medical Center , Mccance Center , Journal Of The Alzheimer Association , Brain Health , Massachusetts General Hospital , Chan School , Public Health , Aging Research , Cance Center , Alzheimer 39s Disease , Medical School , Whole Genome Sequencing , ஒன்றுபட்டது மாநிலங்களில் , ருடால்ப் டான்சி , எமிலி ஹென்டர்சன் , ஆராய்ச்சி அலகு , பெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம் , ம்க்க்யாந்ஸ் மையம் , இதழ் ஆஃப் தி முதுமறதி சங்கம் , மூளை ஆரோக்கியம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை ,