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Study shows evidence-based interventions can improve infant brain health


Study shows evidence-based interventions can improve infant brain health
In the world of neurodevelopment, one thing is clear: the earlier the intervention the better. Infancy is a critical time in brain development, and neuroscientists are increasingly identifying factors that can negatively impact cognition and ones that can improve cognition early in life.
At the annual meeting of the Cognitive Neuroscience Society (CNS), researchers from the University of Minnesota are presenting new work on two early interventions: one on the potential use of engineered gut microbes for antibiotic-exposed infants and another on a choline supplement to treat infants exposed prenatally to alcohol. ....

Marie Hickey , Jeff Wozniak , Emily Henderson , University Of Minnesota , Cognitive Neuroscience Society , Pediatric Research , Nathalie Maitre , Nationwide Children , Cheryl Gale , மேரி ஹிக்கி , ஜெஃப் வோஜ்ணியக் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் மினசோட்டா , அறிவாற்றல் நரம்பியல் சமூகம் , குழந்தை ஆராய்ச்சி , நத்தலி மைத்ரே , நாடு முழுவதும் குழந்தைகள் , செரில் கேல் , புதிதாகப் பிறந்தவர் ,

Optimized nano-micelles can induce efficient genome editing in the mouse brain


Optimized nano-micelles can induce efficient genome editing in the mouse brain
Mar 12 2021
The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain.
The 2020 Chemistry Nobel Prize-winning technology CRISPR/Cas9 holds great promise for treating various diseases such as congenital disorders and viral infections, by correcting the disease-specific genomic sequences.
This technology attracted increasing attention in the last decade as it allows easy targeting of genomic sequences with high precision and low level of undesired off-target gene editing. However, safe and efficient delivery of the Cas9 DNA cutting enzyme and guide RNA (gRNA), which is a short piece of RN ....

Saed Abbasi , Kazunori Kataoka , Kyoto Prefectural University Of Medicine , Innovation Center , Deputy Principal Research Scientist Dr , Deputy Principal Research Scientist , Satoshi Uchida , Associate Professor , Kyoto Prefectural University , Director General , Nobel Prize Winning , Genome Editing , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் ஆஃப் மருந்து , கண்டுபிடிப்பு மையம் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி டாக்டர் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி , சதோஷி உசிதா , இணை ப்ரொஃபெஸர் , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் , இயக்குனர் ஜநரல் , நோபல் ப்ரைஸ் வென்றது , மரபணு திருத்துதல் ,

Study reveals how lung alveolus forms at cellular level


Study reveals how lung alveolus forms at cellular level
Researchers from Children s Hospital of Philadelphia (CHOP) have determined what happens at a cellular level as the lung alveolus forms and allows newborns to breathe air. Understanding this process gives researchers a better sense of how to develop therapies and potentially regenerate this critical tissue in the event of injury. The findings were published online today by the journal
Science.
The lung develops during both embryonic and postnatal stages, during which lung tissue forms and a variety of cell types perform specific roles. During the transition from embryo to newborn is when the alveolar region of the lung refines its primary function of exchanging gas, which includes the critical process of ridding the body of carbon dioxide. ....

University Of Pennsylvania , United States , Jaroda Zepp , Emily Henderson , Division Of Pulmonary , Research Faculty Member , Perelman School Of Medicine , Sleep Medicine , Assistant Professor , Perelman School , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , ஜரோடா ஜேப்ப் , எமிலி ஹென்டர்சன் , பிரிவு ஆஃப் நுரையீரல் , ஆராய்ச்சி ஆசிரிய உறுப்பினர் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , தூங்கு மருந்து , உதவியாளர் ப்ரொஃபெஸர் , பெரல்மேன் பள்ளி , புதிதாகப் பிறந்தவர் ,

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders


Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders
A team of researchers from the Agency for Science, Technology and Research s (A STAR) Genome Institute of Singapore (GIS) have developed a CRISPR-based gene editor, C-to-G Base Editor (CGBE), to correct mutations that cause genetic disorders. Their research was published in
Nature Communications on 2 March 2021.
One in seventeen people in the world suffers from some type of genetic disorder. Chances are, you or someone you know - a relative, friend, or colleague - is one of approximately 450 million people affected worldwide. Mutations responsible for these disorders can be caused by multiple mutagens - from sunlight to spontaneous errors in your cells. The most common mutation by far is the single-based substitution, in which a single-base in the DNA (such as G) is replaced by another base (such as C). Countless cystic fibrosis patients worldwide have C instead of G, leading to ....

Kwei Leong , Emily Henderson , Agency For Science , Genome Institute Of Singapore , Nature Communications , Senior Research Scientist , Genome Institute , C Tog Base Editor , Chew Wei Leong , Young Scientist Award , Patrick Tan , Executive Director , Cystic Fibrosis , Genetic Disorder , வெய் லியோங் , எமிலி ஹென்டர்சன் , மரபணு நிறுவனம் ஆஃப் சிங்கப்பூர் , இயற்கை தகவல்தொடர்புகள் , மூத்தவர் ஆராய்ச்சி விஞ்ஞானி , மரபணு நிறுவனம் , மெல் வெய் லியோங் , இளம் விஞ்ஞானி விருது , பேட்ரிக் பழுப்பு , நிர்வாகி இயக்குனர் , சிஸ்டிக் ஃபைப்ரோஸிஸ் , ஜெநெடிக் கோளாறு ,