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Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target. ....

Luke Gilbert , Kevan Shokat , Kevin Lou , Emily Henderson , Discovery Industry Focus , Goldberg Benioff Endowed Professorship , Prostate Cancer Translational Biology , Small Molecules ,

Aortic Disease Clinical Practice Guidelines (ACC/AHA, 2022)

2022 Clinical practice guidelines on the diagnosis and management of aortic disease from the American College of Cardiology and the American Heart Association, published in the journal Circulation. ....

United States , American Heart Association , American College Of Cardiology , American College , Aortic Dissection , Aortic Dissection Imaging , Abdominal Aortic Aneurysm , Bedside Ultrasonography Evaluation , Thoracic Aortic Aneurysm , Thoracic Endovascular Aortic Repair , Bicuspid Aortic Valve , Coronary Artery Atherosclerosis , Cardiovascular Imaging , Ardiac Imaging , V Imaging , Multidisciplinary Team , Disease Surveillance , Thoracic Surgery , Clinical Guidelines , Endovascular Techniques , Peripheral Vascular Disease , Issection Of The Aorta , Valvular Heart Disease , Genomic Medicine , Edicine Genomic , Genetic Testing ,

Cohort Study Analyzes AD Risk Associated With Parental Atopy

The analysis of AD risk associated with parental atopy in early life "may help to risk stratify infants to optimize early interventions for prevention or early treatment of AD," the authors write. ....

United States , United Kingdom , San Francisco , Cathal Oconnor , Kellym Cordoro , University Of California , University College Cork Ireland , United Kingdom Working Party , Cathalo Connor , University College Cork , Cork Babies After Scope , Longitudinal Impact Using Neurological , Nutritional Endpoints , Birth Cohort , Nt Ears , Allergic Rhinitis , Atopic Dermatitis , Dermatology Pediatric , Skin Care , Genomic Medicine , Edicine Genomic , Preventive Screening , United Kingdom Site Content ,

Cancer Patients Missing Out on Genomic Testing, Targeted Therapy

Despite an extensive body of supportive evidence and recommendations from major cancer societies, many patients with cancer still do not undergo genomic testing or receive appropriate targeted therapy. ....

United States , Foundationone Cdx , Dan Longo , Richardl Schilsky , Centers For Medicare Medicaid Services , National Cancer Institute , American Society Of Clinical Oncology , University Of Chicago , Drug Administration , No Easy Solutions , New England Journal , Medscape Medical , American Society , Clinical Oncology , National Cancer , Medicaid Services , Scandion Oncology , Clarified Precision Oncology , Genomic Medicine , Edicine Genomic , Genetic Testing , Tumor Genetics , Alignant Neoplasia , Targeted Therapy , Biologic Therapy , Genetic Disorder ,

Atopic dermatitis in dogs linked to certain parts of the genome

Using new gene mapping methods, researchers have found connections between atopic dermatitis (eczema) in dogs and several regions of the genome. Some of the genes identified coincide with genes linked to similar problems in humans. ....

United States , United Kingdom , Uppsala Lan , Katarina Tengvall , Kerstin Lindblad Toh , Kerstin Bergvall , Uppsala University , Swedish University Of Agricultural Sciences , Swedish Research Council , Department Of Medical Biochemistry , Communications Biology , European Research Council , Swedish University , Agricultural Sciences , Comparative Genomics , Medical Biochemistry , Medical Specialties , Atopic Dermatitis , Branches Of Biology , Candidate Gene , Genetic Mapping , Typei Hypersensitivity , Whole Genome Sequencing ,