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Creating a toolkit of yeast strains that over-produce key cellular building blocks

Creating a toolkit of yeast strains that over-produce key cellular building blocks
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

City Of , United Kingdom , Huadong Peng , Rodrigo Ledesma Amaro , Imperial College London , Nature Microbiology , Graphpad Prism ,

Study reveals significant health benefits of golden berries in diabetic and obese rats

The effects of a Golden Berry (Physalis peruviana)-enriched diet on insulin resistance and obesity. ....

United States , Berry Physalis , Industrial University Of Santander , Colombian Corporation For Agricultural Research , Golden Berry , Daily Consumption , Has Been Shown , Insulin Resistance , Obese Rats , Image Credit , South American , Colombian Corporation , Agricultural Research , Industrial University , Ingenuity Pathway Analysis , Graphpad Prism , High Density Lipoprotein , Orthogonal Signal Correction , Partial Least Squares Discriminant Analysis , Cyclocitral Glucuronide , Pipecolic Acid , Blood Sugar , High Blood Sugar , Insulin Resistance , Metabolic Disorders , Metabolic Syndrome ,

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , South Korea , Dimethylacetamide Dmac , Nanozoomer Hamamatsu , Kaplan Meier , Ut Southwestern Medical Center , Q Zhong Ut Southwestern Medical Center , Yj Oh Yonsei University , Signalstain Antibody Diluent Cell Signaling Technology , Talazoparib Pfizer Inc , Signalstain Citrate Unmasking Solution Cell Signaling Technology , Ut Southwestern Medical Center Genomics Core , Biosplice Inc , A Kung Dana Farber Cancer Institute , Jackson Laboratory , Proteome Discoverer Software Thermo Fisher Scientific , Therapeutic Oncology Research , Hamon Center , Proteomexchange Consortium , D Baltimore California Institute Of Technology , Drug Administration , Cell Signaling Technology , Tandem Mass Tag , Gene Ontology , Cancer Dependency Map , Drug Sensitivity ,

Salicylic acid enhances cell growth, fatty acid and astaxanthin production in heterotrophic Chromochloris zofingiensis without reactive oxygen species elevation | Biotechnology for Biofuels and Bioproducts

The induction of lipid and astaxanthin accumulation in microalgae is often achieved through abiotic stress. However, this approach usually leads to oxidative stress, which results in relatively low growth rate. Phytohormones, as important small molecule signaling substances, not only affect the growth and metabolism of microalgae but also influence the intracellular reactive oxygen species level. This study aimed to screen phytohormones that could promote the fatty acids and astaxanthin yield of heterotrophic Chromochloris zofingiensis without causing oxidative damage, and further investigate the underlying mechanisms. In the present study, among all the selected phytohormones, the addition of exogenous salicylic acid (SA) could effectively promote cell growth along with the yield of total fatty acids (TFA) and astaxanthin in heterotrophic C. zofingiensis. Notably, the highest yields of TFA and astaxanthin were achieved at 100 μM SA, 43% and 97.2% higher compared with the ....

United States , Santa Clara , American Type Culture Collection , Illumina Novaseq , Graphpad Prism ,

A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large, amphipathic glycolipid called lipopolysaccharide (LPS) in its outer leaflet1. Assembly of the outer membrane requires transport of LPS across a protein bridge that spans from the cytoplasmic membrane to the cell surface. Maintaining outer membrane integrity is essential for bacterial cell viability, and its disruption can increase susceptibility to other antibiotics2–6. Thus, inhibitors of the seven lipopolysaccharide transport (Lpt) proteins that form this transenvelope transporter have long been sought. A new class of antibiotics that targets the LPS transport machine in Acinetobacter was recently identified. Here, using structural, biochemical and genetic approaches, we show that these antibiotics trap a substrate-bou ....

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