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AstraZeneca's Rare Disease Pipeline Notches Another FDA Approval

The FDA approved AstraZeneca drug Voydeya as an add-on to standard therapies for paroxysmal nocturnal hemoglobinuria, a rare blood disorder. Alexion, now AstraZeneca’s rare disease subsidiary, added the small molecule to its pipeline via a 2019 acquisition.

Japan , Amolyt-pharma , Alexion-pharmaceuticals , Astrazeneca , Achillion-pharmaceuticals , Lancet-haematology , Astrazeneca-rare-disease , Weight-loss , Besity , Verweight , Diabetes , Massachusetts

Labcorp's $237M Tuck-In Deal Brings Lab Testing Assets From BioReference Health

Labcorp is buying the clinical diagnostics and reproductive women’s health businesses of BioReference Health, excluding those assets in New York and New Jersey. Labcorp has returned to being fully focused on lab-testing after last year’s spinoff of Fortrea, its former clinical trial services business.

New-york , United-states , Burlington , New-jersey , Michael-cherny , Quest-diagnostics , Covance , Opko-health , Bioreference-health , North-carolina-based-labcorp , Leerink-partners , Opko-chairman

Novo Nordisk Expands Cardio Reach by Buying Heart Drugs Biotech Cardior

Novo Nordisk’s strategy to grow beyond metabolic diseases includes expanding into adjacent areas such as cardiovascular disease. Acquiring Cardio Pharmaceuticals adds a novel RNA-based therapy that is a potential heart failure treatment.

Denmark , Danish , Martin-holst-lange , Novo-nordisk , Valo-health , Cardior-pharmaceuticals , Germany-based-cardior , European-heart , Holst-lange , Weight-loss , Besity , Verweight

AbbVie Gets Another Ulcerative Colitis Contender via $137M Landos Acquisition

AbbVie is acquiring Landos Biopharma, whose lead drug is a small molecule that takes a novel approach to treating ulcerative colitis. Preliminary proof-of-concept data from a Phase 2 study are expected later this year.

Abbvie-landos , Thomas-smith , Abbvie-roopal-thakkar , Abbvie-rinvoq , Landos-biopharma , Chris-garabedian , Scripps-research , Nasdaq , Virginia-based-landos , Roopal-thakkar , Leerink-partners , Federal-trade

Survey: Pharma Commercial Teams Want More Data Analytics Solutions

Lack of automation is the top challenge facing commercialization teams, according to a survey of executives at U.S.-based pharma companies. The survey was conducted in late 2023 and results were reported this month.

California , United-states , Santa-clara , Global-surveyez , Weight-loss , Besity , Verweight , Diabetes , Massachusetts , Medical-devices , Obesity

Vitality in the Supply Chain: The Limitless Potential of ATMPs

The “holy grail” of ATMP-based treatments is to provide cures for some of the world’s most debilitating disease states, but for this to occur, a unified front is needed to democratize these therapies – collaboration from industry, academia, supply chain and, indeed, clinicians and hospitals is paramount to ensuring safe manufacturing and transit.

Canada , Canadian , Vertex-pharmaceuticals , Weight-loss , Besity , Verweight , Diabetes , Massachusetts , Medical-devices , Obesity , Startups

Lose Fat, Not Muscle: Next Test for Lilly's Zepbound Pairs It With BioAge Drug

In preclinical testing, combining BioAge Labs’ experimental drug with Eli Lilly weight drug Zepbound led to greater weight loss compared with Zepbound alone. Now the company plans to run a Phase 2 study to see if it can replicate those results in humans.

Cambridge , Cambridgeshire , United-kingdom , Redwood-city , California , United-states , Columbus , Ohio , Chapel-hill , Thousand-oaks , Delaware , Deerfield

Bavarian Nordic Hones Infectious Disease Focus by Dropping Cancer Vaccine R&D

Bavarian Nordic will concentrate on its portfolio and pipeline of infectious diseases vaccines, including top seller Jynneos, approved for mpox and smallpox. The company only had one clinical-stage cancer vaccine program.

Denmark , Danish , Bavarian-nordic , Gritstone-bio , Weight-loss , Besity , Verweight , Diabetes , Massachusetts , Medical-devices , Obesity

Novavax and Gavi Settle Dispute Over Covid Vaccines Pact, Avoiding Arbitration

By settling now and agreeing to deferred payments over the next five years, Novavax avoids the risk of being responsible for a much bigger payout all at once. The arbitration hearing over the disputed vaccine purchase agreement with Gavi was scheduled for this summer.

David-marlow , John-jaocbs , Gavi-covid , International-court , Vaccine-alliance , World-health-organization , Maryland-based-novavax , Advance-market-commitment , Novavax-president , Weight-loss , Besity , Verweight

Adverse Event Prompts FDA Hold on Tests of Drug in Atopic Dermatitis & Asthma

The FDA clinical hold follows a a report of liver failure that may be associated with zelnecirnon, an experimental Rapt Therapeutics drug. The biotech notes that no other patient has experienced liver problems and this safety signal has not been seen in any other tests of the molecule.

Brian-wong , Regeneron-pharmaceuticals , San-francisco-based-rapt , Weight-loss , Besity , Verweight , Diabetes , Massachusetts , Medical-devices , Obesity , Startups , Healthcare-innovation