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Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model. ....

United States , Miguel Sobral , Robertp Pinkas , Yoav Binenbaum , Yutong Liu , Donald Ingber , Dave Mooney , David Mooney , David Zhang , Joshua Brockman , Kwasi Adu Berchie , Drug Administration , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes Of Health , University Of Wisconsin , Wyss Institute , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical , Wyss Founding Core Faculty , Family Professor , Postdoctoral Fellow , Assistant Professor ,

Feed My Sheep in Temple holding laundry detergent drive to meet high demand for free laundry services

Feed My Sheep in Temple holding laundry detergent drive to meet high demand for free laundry services
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United States , Casey Mooney , Lorenda Tyree , Kristina Omisola , Feed My Sheep ,