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Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial | Psychiatry and Behavioral Health | JAMA Psychiatry

This randomized clinical trial evaluates the combination of psychotherapy with psilocybin vs active placebo in patients with alcohol use disorder. ....

United States , New York , Purdue University , West Lafayette , New York University , New Mexico , University Of New Mexico , Ceruvia Lifesciences , David Nichols , Nicholas Cozzi , Michaelp Bogenschutz , Claudia Turnbull , National Institute On Drug Abuse , Health Connections , B More Inc , David Nichols At Purdue University , Polaris Insight Center , Administration Of Study Medication , Translational Sciences , Riverstyx Foundation , York University , Indivior Inc , Beckley Psytech , National Institutes Of Health , World Health Organization , Drug Administration ,

Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants

In a cohort study, Jessica Gong and colleagues investigate associations between reproductive factors, number of children, and dementia among individuals in the UK Biobank. ....

New South Wales , United Kingdom , United States , South Korea , Kaiser Permanente , Carol Brayne , Research Ethics Committee , Rstudio Team , United Kingdom Biobank Outcome Adjudication Group , Australian National Health , International Consortium , Program Grant , Research Tissue Bank , Stata Statistical Software , Research Council Investigator Grant , University Of Cambridge , Women Health Initiative Study , Clinical Practice Research Datalink , University Of New South Wales , National Research Ethics Service , United Kingdom Biobank , Creative Commons Attribution License , Scientia Phd , Medical Research Council Investigator Grant , Cohort Studies , International Classification ,

Temporal changes in factors associated with COVID-19 vaccine hesitancy and uptake among adults in Hong Kong: Serial cross-sectional surveys

Temporal changes in factors associated with COVID-19 vaccine hesitancy and uptake among adults in Hong Kong: Serial cross-sectional surveys
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Hong Kong , University Of Hong Kong , Hong Kong General , Sanofi Pasteur , Health Bureau Of The Hong Kong , World Health Organization , Centre For Health Protection , Hong Kong Centre For Health Protection , Lancet Group , University Of Hong Kong Reference No , Research Fund , R Foundation For Statistical Computing , Medical Research Fund , World Health , Cantonese Speaking Hong Kong , Infect Dis , Hong Kong Centre , Multivariate Imputation , Chained Equations , Statistical Computing , Institutional Review Board , Hong Kong Special Administrative Region , Health Bureau ,

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial
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United Kingdom , Danielle Samulski , Pediatr Pulmonol , J Stat Software , Respir Med , Cyst Fibros , Database Syst Rev , Englj Med , Parent Cystic Fibrosis Questionnaire , Multivariate Imputation , Chained Equations , Stat Software , Interdiscip Rev Comput Stat , Open Res ,

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID-19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent on ....

United Kingdom , United States , City Of , La Jolla , Oxford Immunotech , Jeremyj Farrar , Quanterix Billerica , Nahoko Shindo , Milliporesigma Burlington , Ethics Review Committee , Imperial Biomedical Research Centre , Scotlanda Research Ethics Committee Ref , Oxfordc Research Ethics Committee , Material Access Committee , Zoonotic Infections At University Of Liverpool , Health Protection Research Unit , World Health Organization , Tissue Bank Ethics Committee Approval , Health Protection Research Senior Investigator , Liverpool Experimental Cancer Medicine Centre , Infections At Imperial College London , United Kingdom Coronavirus Immunology Consortium , National Institute For Health Research United Kingdom , Fulham Research Ethics Committee , Department For International Development , Melinda Gates Foundation ,