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Key Points - U.S. hospitals, health systems, suppliers, pharmaceutical companies and other industry stakeholders are invited to submit voluntary pledges to reduce...
The emplacement of the Siberian Traps, the Central Atlantic Magmatic Province (CAMP) and the Wrangellia have been linked to end-Permian, end-Triassic mass extinctions, and to the Carnian Pluvial Episode (CPE), respectively. Exploring the timing, eruptive styles, and volatile degassing of these Large Igneous Provinces (LIPs) is crucial to understand their causal link to the catastrophic environmental crises that punctuated the Triassic. In this study we review the main characteristics of these LIPs, emphasizing common features and differences, and discussing aspects that are still in debate. Es...
Autoimmune toxicities, while common following treatment with cancer immunotherapies, are not well-characterized in patients treated with BRAF/MEK inhibitors. Emerging data suggest that autoimmune effects may be linked with superior responses to both treatment modalities; however, there is little evidence describing mechanisms of immune-related toxicity for patients on BRAF/MEK inhibitors. Here we describe the experience of a 59-year-old HLA-A2, A29, B27-positive male patient with recurrent/metastatic melanoma. After progression on checkpoint inhibitor therapy, he was treated with dabrafenib/tr...
US President Joe Biden on Friday (local time) held a video call with his Chinese counterpart Xi Jinping and warned China of implications and consequences if Chi
US President Joe Biden on Friday (local time) held a video call with his Chinese counterpart Xi Jinping and warned China of implications and consequences if Chi