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Research may lead to a significant breakthrough in the battle against deadly brain tumors

Research may lead to a significant breakthrough in the battle against deadly brain tumors
Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. To begin with, the researchers identified a failure in the brain s immune system, leading to the amplification of cell division and spread of Glioblastoma cancer cells. The failure results partially from the secretion of a protein called P-Selectin (SELP), which, when bound to its receptor on the brain immune cells, alters their function so that instead of inhibiting the spread of cancer cells, they do the opposite, enabling them to proliferate and penetrate brain tissues. ....

United States , Eilam Yeini , Ronit Satchi Fainaro , Asaf Madi , Emily Henderson , Johns Hopkins University , Israel Cancer Research Fund , Nature Communications , Lieber Institute , Head Of The Cancer Research , Israel Science Foundation , Nanomedicine Laboratory , Israel Cancer Association , Morris Kahn Foundation , Cancer Biology Research Center , Tel Aviv Sourasky Medical Center Ichilov , Kadar Family Awards For Outstanding Research , Tel Aviv University Sackler Faculty Of Medicine , European Research Council , Tel Aviv University , Cancer Research , Sackler Faculty , Tel Aviv Sourasky Medical Center , Kadar Family Awards , Outstanding Research , Immune System ,

Researchers develop broad-spectrum SARS-CoV-2 RBD-based vaccine

In a recent bioRxiv preprint, the large team of researchers evaluated a SARS-CoV-2 Spike receptor-binding domain ferritin nanoparticle protein vaccine (RFN) in a nonhuman primate challenge model. This study addresses the need for a next-generation, efficacious vaccine with an increased pan-SARS breadth of coverage. ....

Ramya Dwivedi , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ரம்யா டுவிவேடி , சர்வதேச பரவல் , கொரோனா வைரஸ் , நானோ துகள்கள் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Pregnant women transmit SARS-CoV-2 and vaccine-induced antibodies to fetus

Pregnant women are at high risk for severe COVID-19 infection and death. Yet, insufficient safety data on babies has led many guidelines to leave the decision-making and potential threats to future mothers. While the vaccine trials did not directly test pregnant women, more real-world data suggests the vaccine may provide immunity benefits to newborns through breastmilk. ....

Israel General , Jocelyn Solis Moreiraapr , Jocelyn Solis Moreira , Hebrew University Of Jerusalem , Michal Kovo , Hebrew University , Efficient Maternal , Image Credit , All Pairwise Comparisons Test , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , இஸ்ரேல் ஜநரல் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , ஹீப்ரு பல்கலைக்கழகம் ஆஃப் ஏருசலேம் , ஹீப்ரு பல்கலைக்கழகம் , படம் கடன் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

The role and ancestry of the SARS-CoV-2 spike protein glycan shield

The role and ancestry of the SARS-CoV-2 spike protein glycan shield
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is a class I fusion glycoprotein responsible for interacting with the angiotensin-converting enzyme 2 (ACE2) receptor on the surface of human cells, enabling cell entry. It is the primary target of both natural and vaccine-acquired neutralizing antibodies.
The spike protein is coated in a thick glycan shield that plays a role in target site recognition, towards both the ACE2 receptor and neutralizing antibodies, and in conformational stability, modulating the state of the spike protein between closed and open forms and granting stability to the open prefusion form, which affords enhanced affinity towards the ACE2 receptor by presenting the receptor-binding domain. ....

Michael Greenwood , Panela Structure , Sars Cov 2 , Spike Protein , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

L452R and Y453F SARS-CoV-2 mutations increase transmission and evade immunity

Mutations from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have created multiple variants. Some variants, such as those found in South Africa and Brazil, have caused concern for their potential to evade the immune response. While vaccination efforts are underway, the world is racing against the viruses’ ability to evolve under selective pressure. ....

South Africa , United States , Jocelyn Solis Moreira , Jocelyn Solis Moreiraapr , Sars Cov 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Human Leukocyte Antigen , Immune Response , Protein Stability , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , ப்ரோடீந் ஸ்திரத்தன்மை , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,