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Substrain of SARS-CoV-2 variant in UK may resist antibody neutralization


Substrain of SARS-CoV-2 variant in UK may resist antibody neutralization
Researchers at the Polish Academy of Sciences in Warsaw have identified a substrain of the recently emerged B.1.1.7 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may confer resistance to antibody neutralization.
The SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that has now claimed the lives of more than 2.35 million people.
The substrain of the B.1.1.7 variant of concern (VOC) contains mutations that have previously been shown to compromise the binding of neutralizing antibodies.
Tomasz Lipniacki and colleagues say mutations in the receptor-binding domain (RBD) of the viral spike protein are of particular concern, especially those identified in the receptor-binding motif (RBM). ....

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Both mRNA vaccines protect against emerging variants of SARS-CoV-2


Both mRNA vaccines protect against emerging variants of SARS-CoV-2
Researchers in the United States and Canada have conducted a study showing that just a single dose of either the Pfizer-BioNTech or Moderna vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is likely to protect against emerging variants.
The SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to pose a significant threat to global public health and the worldwide economy.
The Pfizer-BioNTech and Moderna COVID-19 vaccines are based on the spike protein of a SARS-CoV-2 strain (Wuhan-Hu-1) that was isolated in December 2019. The spike protein is the surface structure the virus uses to bind to and infect host cells. ....

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