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Bioengineered ankyrin compounds show high in vitro activity against SARS-CoV-2 mutants

A new study describes the use of DARPin (designed ankyrin repeat proteins) therapeutic agents, each of which contains three different DARPin domains within the same molecule. ....

South Africa , United Kingdom , South African , Liji Thomas , Coronavirus Disease Covid 19 , In Vitro , Sars Cov 2 , Corona Virus , Monoclonal Antibody , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , இல் விட்ரோ , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Novel immunotherapy approach to revert the main hallmarks of cat allergy

Novel immunotherapy approach to revert the main hallmarks of cat allergy
Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system s allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy.
The researchers analyzed the molecular mechanisms underlying this tolerance and proposed a pre-clinical allergen-specific immunotherapy approach to improve the treatment and control of this common type of allergy. The full study results were published recently in the renowned international journal ....

Markus Ollert , Emily Henderson , Department Of Infection , Immunity Of The Luxembourg Institute Health , European Academy Of Allergy , Luxembourg Institute , European Academy , Clinical Immunology , Natural Killer , Tumour Necrosis Factor , Senior Lead , Cat Allergy , Anti Inflammatory , Immune Response , Immune System , எமிலி ஹென்டர்சன் , துறை ஆஃப் தொற்று , நோய் எதிர்ப்பு சக்தி ஆஃப் தி லக்ஸம்பர்க் நிறுவனம் ஆரோக்கியம் , ஐரோப்பிய கலைக்கழகம் ஆஃப் ஒவ்வாமை , லக்ஸம்பர்க் நிறுவனம் , ஐரோப்பிய கலைக்கழகம் , மருத்துவ நோயெதிர்ப்பு , இயற்கை கில்லர் , மூத்தவர் வழி நடத்து , பூனை ஒவ்வாமை , நோயெதிர்ப்பு சிகிச்சை ,

Alpaca nanobodies neutralize SARS-CoV-2 in vitro

A new preprint research paper posted to the bioRxiv server reports the development of highly effective neutralizing nanobodies targeting the viral receptor-binding domain (RBD), thus disrupting its engagement with the host cell angiotensin-converting enzyme 2 (ACE2) receptor. ....

Liji Thomas , Hetero Bivalent Alpaca Nanobodies Targeting , Spike Receptor Binding , Image Credit , In Vitro , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஸ்பைக் ஏற்பி பிணைப்பு , படம் கடன் , இல் விட்ரோ , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Researchers develop rapid COVID-19 diagnostic test affordable for low-income families

Researchers develop rapid COVID-19 diagnostic test affordable for low-income families
A test that detects antibodies to the novel coronavirus in 10 minutes and costs only a fifth of the market average has been developed by researchers at the University of São Paulo s São Carlos Chemistry Institute (IQSC-USP) and Brazilian startup Biolinker, with São Paulo Research Foundation - FAPESP s support.
The device works similarly to the rapid tests available now in pharmacies. It analyzes a drop of blood, and two red LEDs light up if it detects the presence of immunoglobulin G (IgG) antibodies, which are produced in the acute phase of COVID-19 (ten days after the onset of symptoms on average). ....

Karla Castro , Carlos Ufscar , Isabela Mattioli , Mona Oliveira , Frank Crespilho , Paulo Bioelectrochemistry , Emily Henderson , Innovative Research In Small Business Program , Paulo Research Foundation , Paulo State University , Interface Laboratory , Carlos Chemistry Institute , Paulo Research Foundatin , Brazilian Innovation Agency , Small Business Program , Brazilian Innovation , Federal University , Corona Virus , Spike Protein , கர்லா காஸ்ட்ரோ , இசபெலா மததீொளி , மோனா ஆலிவேரா , எமிலி ஹென்டர்சன் , புதுமையானது ஆராய்ச்சி இல் சிறிய வணிக ப்ரோக்ர்யாம் , பாலொ ஆராய்ச்சி அடித்தளம் , பாலொ நிலை பல்கலைக்கழகம் ,

Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases

Researchers find possible cause for self-destructive immune system attacks in autoimmune diseases
Autoimmune diseases, in which the body s own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities.
The immune system can be a mixed blessing: Usually it is highly effective in protecting the human organism against bacteria, viruses and mycosis and even cancer. But these defense cells can also turn against the body s own tissues and trigger autoimmune diseases, including for example rheumatoid arthritis and systemic lupus erythematosus, an illness involving chronic dermatitis and inflammation of the joints, the nervous system and internal organs or even become cancer cells themselves and dev ....

Maike Buchner , Juergen Ruland , Emily Henderson , Technical University Of Munich , German Research Foundation , Institute Of Clinical Chemistry , Institute For Clinical Chemistry , Technical University , Clinical Chemistry , Research Foundation , Leibniz Prize , Receptor Activator , Autoimmune Disease , Immune System , Lupus Erythematosus , Nervous System , Rheumatoid Arthritis , Systemic Lupus Erythematosus , ஜூர்கன் ருளந்ட் , எமிலி ஹென்டர்சன் , தொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , நிறுவனம் ஆஃப் மருத்துவ வேதியியல் , நிறுவனம் க்கு மருத்துவ வேதியியல் , தொழில்நுட்ப பல்கலைக்கழகம் , மருத்துவ வேதியியல் ,