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Scientists Apply High-resolution, Single-cell Profiling to Understand Immune Response in Severe COVID-19

A new study by Yale researchers provides a single-cell resolution profile of the inflammatory severe COVID-19 disease, and the loss of coordination between the

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Immune response may pose greater risk to pregnant women than COVID virus


By Bill Hathaway
April 22, 2021
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For reasons not yet clear, pregnant women infected with the virus that causes COVID-19 are more likely to experience preterm births, pre-eclampsia, and other neonatal problems than non-infected women.
A team of Yale scientists decided to investigate whether the virus could be affecting placental tissue of infected expectant mothers. Their analysis found that while evidence of the virus in the placenta is rare, the placenta in infected mothers tended to exhibit a much higher level of immune system activity than those of non-infected pregnant women, they report April 22 in the journal Med.

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Covid infection raised mortality risk during pregnancy: Study


Covid infection raised mortality risk during pregnancy: Study
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New York, April 23 : Women, who contracted Covid-19 during their pregnancy were 20 times more likely to die than those who did not contract the virus, according to a worldwide study of 2,100 women.
The study, led by researchers from the Universities of Washington and Oxford, involved pregnant women from 43 maternity hospitals in 18 low-, middle- and high-income nations. In the study conducted between April and August of 2020, each woman affected by Covid-19 was compared with two uninfected pregnant women who gave birth during the same span in the same hospital.

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Weak Immune System Poses Greater Risk for Pregnant Women


Weak Immune System Poses Greater Risk for Pregnant Women
by Hannah Joy on 
April 23, 2021 at 5:36 PM
Covid-19 does not affect the placental tissue of infected expectant mothers
As, the placenta exhibits a much higher level of immune system activity
Pregnant women who have a weak immune system are at greater risk of contracting the Covid-19 virus. However, having a healthy immune system, protects the fetus from being infected, reveals a new study.
For reasons not yet clear, pregnant women infected with the virus that causes COVID-19 are more likely to experience preterm births, pre-eclampsia, and other neonatal problems than non-infected women.

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Immune system, not COVID virus, may pose greatest risk to pregnant women


Yale University
For reasons not yet clear, pregnant women infected with the virus that causes COVID-19 are more likely to experience preterm births, pre-eclampsia, and other neonatal problems than non-infected women.
A team of Yale scientists decided to investigate whether the virus could be affecting placental tissue of infected expectant mothers. Their analysis found that while evidence of the virus in the placenta is rare, the placenta in infected mothers tended to exhibit a much higher level of immune system activity than those of non-infected pregnant women, they report April 22 in the journal Med.
“The good news is the placenta is mounting a robust defense against an infection that is far distant, in lungs or nasal tissue,” said Shelli Farhadian, assistant professor of internal medicine (infectious diseases) and neurology at Yale and co-corresponding author. “On the other hand, the high level of immune system activity might be leading to other deleterious effects on the pregnancy.”

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Immune system, not COVID virus, may pose greatest risk to pregnant women

Immune system, not COVID virus, may pose greatest risk to pregnant women
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Researchers Connect Spinal Fluid Autoantibodies to Neurological Symptoms in COVID-19 Patients


February 15, 2021
by Julie Parry
In March of 2020, Shelli Farhadian, MD, PhD, assistant professor of medicine (infectious diseases) and neurology, began to see parallels in her pre-pandemic research on neurologic effects in patients with HIV infection and the possibility of neurologic effects on patients with SARS-CoV-2, or COVID-19.
“There was some literature out there that suggested that coronaviruses could have an effect on the brain. So, knowing that that was a potential possibility, even before we had our first case at Yale New Haven Hospital, I worked with other people to set up a protocol where we could consent patients to collect tissue specimens and information to try to see if this was also going happen with SARS-CoV-2,” explained Farhadian.

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