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Frontiers | Characterizing the Severity of SARS-CoV-2 Variants at a Single Pediatric Center

Since March 2020, SARS-CoV-2 has plagued the world with COVID-19 and individuals of all ages have experienced varying symptoms of disease. Older adults were experiencing more severe disease compared to children and were prioritized by vaccination efforts. While biologic therapies and vaccinations were implemented, there were changes in public health restrictions with subsequent surges resulting in more infected children. During these surges there was a rise of different SARS-CoV-2 variants with the dominant variant initially alpha (B.1.1.7 and other Pango lineages) and epsilon (B.1.427/B.1.429) in early 2021 and a dramatic shift to delta (B.1.617.2 and other Pango lineages) by mid-summer 2021. In this study we aimed to characterize the clinical severity and host factors associated with disease by SARS-CoV-2 variant and evaluate if there are differences in disease severity by circulating variant. We retrospectively included all individuals 0-25 years of age who presented to our center a ....

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Impact of rapid and comprehensive RT-qPCR for detecting SARS-CoV-2 variants of concern

Researchers reported the development and validation of a two-reaction multiplex reverse transcription-quantitative polymerase chain reaction genotyping strategy that distinguishes SARS-CoV-2 variants of concern. ....

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Scientists say a 'doomsday' variant after delta isn't likely. But here's what's possible

Health experts have considerable uncertainty about how the pandemic will evolve, but at. ....

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How scientists are already hunting for California's next COVID variant

California has dramatically improved its genomic sequencing capacity since the start of. ....

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Rise of coronavirus variants will define the next phase of the pandemic in the US

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WASHINGTON Variants of the coronavirus are increasingly defining the next phase of the pandemic in the United States, taking hold in ever-greater numbers and eliciting pleas for a change in strategy against the outbreak, according to government officials and experts tracking developments.
The highly transmissible B.1.1.7 variant that originated in the United Kingdom now accounts for 27% of all cases in this country. It is the most common variant in the United States, Rochelle Walensky, director of the Centers for Disease Control and Prevention, said Wednesday a development that officials predicted months ago. Two other variants, which took root in South Africa and Brazil and also are more transmissible, are cropping up with increasing frequency in parts of the United States. ....

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