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A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics | Infectious Diseases of Poverty

Dengue is the fastest spreading arboviral disease, posing great challenges on global public health. A reproduceable and comparable global genotyping framework for contextualizing spatiotemporal epidemiological data of dengue virus (DENV) is essential for research studies and collaborative surveillance. Targeting DENV-1 spreading prominently in recent decades, by reconciling all qualified complete E gene sequences of 5003 DENV-1 strains with epidemiological information from 78 epidemic countries/areas ranging from 1944 to 2018, we established and characterized a unified global high-resolution genotyping framework using phylogenetics, population genetics, phylogeography, and phylodynamics. The defined framework was discriminated with three hierarchical layers of genotype, subgenotype and clade with respective mean pairwise distances 2–6%, 0.8–2%, and ≤ 0.8%. The global epidemic patterns of DENV-1 showed strong geographic constraints representing stratified spatial ....

United States , South Korea , Republic Of Korea , Koichiro Tamura , Monte Carlo , Sudhir Kumar , Masatoshi Nei , Pennsylvania State University , R Foundation For Statistical Computing , Virus Pathogen Resource , Hierarchical Bayesian Analysis , Population Structure , Tabless B , Bayesian Skyline , Markov Chain Monte Carlo , Trace Tracer , Statistical Computing ,

Nutrition-related diseases and cardiovascular mortality in American society: national health and nutrition examination study, 1999–2006 | BMC Public Health

Despite many significant advances in treatment and management, cardiovascular disease remains the main cause of the global disease burden. Nutrition-related disease is a modifiable cardiovascular risk factor. However, few studies have examined the relationship between nutrition-related diseases and cardiovascular mortality. We aimed to investigate the association of nutrition-related diseases with cardiovascular mortality based on a large nationally representative community population. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999–2006 with mortality follow-up through December 31, 2015. Finally, 12,469 participants were analyzed. Each participant was assigned to one of four groups: normal nutrition without sarcopenia, sarcopenia with normal nutrition, malnutrition without sarcopenia, and malnutrition-sarcopenia syndrome. Survival curves and Cox regressions based on the NHANES recommended weights were used to assess the association betwee ....

United States , Centers For Disease , Nutrition Examination Survey , Foundation For The National Institutes Of Health , National Center , International Classification Of Diseases , National Health , National Death Index , Hologic Inc , Health Statistics , R Foundation For Statistical Computing , Disease Control , National Institutes , Controlling Nutritional Status , Supplementary Table , Accessed July , International Classification , Statistical Computing ,