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Acute exposure to air pollutants increase the risk of acute glaucoma | BMC Public Health

Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults. We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model. A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxi ....

Eteläuomen Läi , China National Urban Air Quality Publishing Platform , China Meteorological Data Sharing Service System , Throat Hospital Of Fudan University , R Foundation For Statistical Computing , Eye Ear Nose , Throat Hospital , Fudan University , Xinhua Hospital Affiliated , Shanghai Jiao Tong University School , Institutional Review Board , National Urban Air Quality Real Time Publishing , Statistical Computing ,

Cureus | Evaluation of Short-Term Symptoms Associated With COVID-19 Vaccines Used Among Adolescents in Saudi Arabia

Objectives: Several government-sponsored reporting systems have stated mild to moderate side effects of COVID-19 vaccines. However, patient-reported data on COVID-19 vaccine-associated adverse effects in adolescents are lacking. Our objective was to assess the short-term side effects of Pfizer-BioNTech BNT162b2 or Moderna mRNA-1273 vaccinations among teenagers in Saudi Arabia.

Methods: A retrospective, cross-sectional study was conducted among individuals aged 12-18 years old who received one of the two mentioned vaccines between July 2021 and March 2022 in Riyadh, Saudi Arabia.

Results: The most common short-term side effects reported for COVID-19 vaccines among teenagers in our study were fatigue, pain at the site of injection, fever, chills, headache, nausea, and vomiting. Female participants, individuals who had a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and those who received two doses of the vaccine are at higher ri ....

United States , Saudi Arabia , Eteläuomen Läi , Ar Riya , Kingdom Of Saudi Arabia , Transparency Initiative , World Health Organization , Drug Administration , Dar Al Uloom University , Qpr Software , College Of Medicine , Drug Authority , R Foundation For Statistical Computing , Saudi Food , Institutional Review Board , Google Forms , American Association , Public Opinion Research , Statistical Computing ,

Indigenous adolescent health in Aotearoa New Zealand: Trends, policy and advancing equity for rangatahi Maori, 2001–2019

Indigenous adolescent health in Aotearoa New Zealand: Trends, policy and advancing equity for rangatahi Maori, 2001–2019
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New Zealand , New Zealand General , Tai Tokerau , Ovid Medline , Le Grice , Tiritio Waitangi , Health Research Council Of New Zealand Project , Victoria University Of Wellington , Rangatahi Smart , Core Team , Ministry Of Health , Eurj Public Health , University Of Auckland Human Participants Ethics Committee , University Of Auckland , R Foundation For Statistical Computing , Health Research Council Of New Zealand , Aotearoa New Zealand , Critical Te Tiriti Analysis , Health Research Council , New Zealand Project Grants , Smart Survey , Initial Findings , Victoria University , Auckland Human Participants Ethics Committee , Supplementary Table , Statistics New Zealand ,

Associations between insomnia and pregnancy and perinatal outcomes: Evidence from mendelian randomization and multivariable regression analyses

Using Mendelian randomization and observational analyses, Qian Yang and colleagues investigate the associations between insomnia and stillbirth, miscarriage, gestational diabetes, hypertensive disorders of pregnancy, perinatal depression, preterm birth, and low and high birth weight. ....

City Of , United Kingdom , North Yorkshire , Southwest Finland , Jebsen Stiftelsen , Stiftelsen Kristian Gerhard Jebsen , United Kingdom Medical Research Council , International Classification Of Diseases , Us National Institute Of Health , University Of Bristol , Research Council Of Norway , European Union Horizon , Diabetes Research , A National Institute Of Health Research , Regulatory Agency , Immediate Postdoctoral Basic Science Research Fellowship , Wellcome Trust Sanger Institute , Health Research Collaboration Yorkshire , Neale Lab , Moba Scientific Management Group , High Court , Norwegian Institute Of Public Health , Skilled Development Fellowship , British Heart Foundation , Wellcome Trust , Norway Health Authority ,

l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study | BMC Medicine

L-carnitine is emerging as an item of interest for cardiovascular disease (CVD) prevention and treatment, but controversy exists. To examine the effectiveness and safety of l-carnitine, we assessed how genetically different levels of l-carnitine are associated with CVD risk and its risk factors. Given higher CVD incidence and l-carnitine in men, we also examined sex-specific associations. We used Mendelian randomization to obtain unconfounded estimates. Specifically, we used genetic variants to predict l-carnitine, and obtained their associations with coronary artery disease (CAD), ischemic stroke, heart failure, and atrial fibrillation, as well as CVD risk factors (type 2 diabetes, glucose, HbA1c, insulin, lipid profile, blood pressure and body mass index) in large consortia and established cohorts, as well as sex-specific association in the UK Biobank. We obtained the Wald estimates (genetic association with CVD and its risk factors divided by the genetic association with l-carnitine ....

Eteläuomen Läi , United Kingdom , Finngen Biobank , Research Ethics Committee , Global Lipids Genetics Consortium , Patient Information Advisory Group , Neale Lab , Saf Consortium , Community Health Index Advisory Group , R Foundation For Statistical Computing , United Kingdom Biobank , Heart Failure Molecular Epidemiology , Therapeutic Targets , United Kingdom Biobank Axiom , Genetic Investigation , Statistical Computing , United Kingdom Biobank Resource , North West Multi Centre Research Ethics Committee ,