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Acupuncture Treatment Reduced the Risk of Heart Disease

14 TCAs have cardiac toxicity, and SNRIs have complications related to hypertension.
15,16 Patients should be closely observed when they have these prescriptions. There is no evidence that shows that patients with depression have a reduced risk of CHD with the other antidepressants. Thus, clinical doctors have a great interest in finding a treatment not only for treating depression but also for reducing CHD risk. SSRIs have been recommended by the American Heart Association (AHA) for treating CHD patients with depression because of their safety.
17 Although some studies have shown the effectiveness of acupuncture in patients with depression,
18,19 less evidence could be found from long-term follow-up studies to show that patients with depression have CHD protection with acupuncture treatment. The National Health Insurance (NHI) program was established in 1995 in Taiwan by the National Health Insurance Administration. ....

United States , Taiwanese National Health Insurance Research Database , American Heart Association , Longitudinal Health Insurance Database , International Classification Of Diseases , Research Ethics Committee Of China Medical University , National Health Insurance , National Health Insurance Administration , R Foundation For Statistical Computing , Insurance Database , International Classification , Ninth Revision , Clinical Modification , Research Ethics Committee , China Medical University , Disease Categories , Statistical Computing , Depression Who Received Acupuncture Therapy , Depression Who Did Not Receive Acupuncture , Hazard Ratios , Confidence Intervals , Coronary Heart Disease Associated , Receiving Acupuncture , Covariates Among Patients , Coronary Heart Disease , Depression Who Received ,

Long-chain polyphosphates impair SARS-CoV-2 infection and replication

Long-chain polyphosphates impair SARS-CoV-2 infection and replication
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , United States , Oxford Nanopore , Autodock Vina , Clustal Omega , Azienda Ospedaliera Universitaria Federico , Napoli Federico , Rr Core Team , Drug Administration , Foundation For Statistical Computing , Prosci Inc , Wyatt Technology , Immunoreagents Inc , Cell Signaling Technology , Agilent Technology , Middle East , Force Covid , Direzione Sanitaria , Dipartimento Di Medicina Molecolare , Biotecnologie Mediche , Hilymaxtransfection Reagent , Graphpad Prism , Thermo Fisher Scientific , Applied Biosystems , Foster City , British United Kingdom ,

Phenotypes of Mild-to-Moderate Obstructive Pulmonary Disease

Purpose: Asthma and chronic obstructive pulmonary disease (COPD) are complex and heterogeneous inflammatory diseases. We sought to investigate distinct disease profiles based on clinical, cellular and molecular data from patients with mild-to-moderate obstructive pulmonary diseases.
Patients and Methods: Patients with mild-to-moderate allergic asthma (n=30) and COPD (n=30) were prospectively recruited. Clinical characteristics and induced sputum were collected. In total, 35 mediators were assessed in induced sputum. Logistic regression analysis was conducted to identify the optimal factors that were able to discriminate between asthma and COPD. Further, the data were explored using hierarchical clustering in order to discover and compare clusters of combined samples of asthma and COPD patients. Clinical parameters, cellular composition, and sputum mediators of asthma and COPD were assessed between and within obtained clusters. ....

United States , Waals Gewest , Eteläuomen Läi , Biomedica Medizinprodukte Gmb , Global Initiative For Chronic Obstructive Lung Disease , American Thoracic Society European Respiratory , University Of Warsaw , Statsoft Inc , R Foundation For Statistical Computing , Global Initiative For Asthma , Medical University , Global Initiative , Chronic Obstructive Lung , Port Washington , Ethics Committee , American Thoracic , European Respiratory Society , Elecsys Ige , Roche Diagnostics Gmbh , Bio Plex Pro , Human Cytokine , Bio Rad Laboratories , Demeditec Diagnostics Gmbh , Biomedica Medizinprodukte Gmbh , Whitneyu Test , Statistical Computing ,

Frontiers | A Disrupted Historical Fire Regime in Central British Columbia

Department of Forest and Conservation Sciences, Faculty of Forestry, University of British Columbia, Vancouver, BC, Canada
In the 2017 and 2018, 2.55 million hectares burned across British Columbia, Canada, including unanticipated large and high-severity fires in many dry forests. To transform forest and fire management to achieve resilience to future megafires requires improved understanding historical fire frequency, severity, and spatial patterns. Our dendroecological reconstructions of 35 plots in a 161-hectare study area in a dry Douglas-fir forest revealed historical fires that burned at a wide range of frequencies and severities at both the plot- and study-area scales. The 23 fires between 1619 and 1943 burned at intervals of 10–30 years, primarily at low- to moderate-severity that scarred trees but generated few cohorts. In contrast, current fire-free intervals of 70–180 years exceed historical maximum intervals. Of the six widespread fires from 1790 to 1905, the 1 ....

United Kingdom , Greenwood Village , United States , British Columbia , New Mexico , Williams Lake , Jasper National Park , New Zealand , Oregon State University , Washington State University , Redwood National Park , Cdendro Larsson , Yocom Kent , Klamath Siskiyou Ecoregion , Coorecorder Larsson , B Hughes Pullman , Secwepemc Shuswap , Ecological Restoration Institute , Burn Plan Framework Development , Laboratory Of Tree , Canadian Institute Of Forestry , Coorecorder Program , University Of British Columbia , Alex Fraser Research Forest , Forest Research Program , Qelmucw Northern Shuswap Tribal Council ,

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SARS-CoV-2 variants with multiple spike mutations enable increased transmission and antibody resistance. Here, we combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants showed increased ACE2 receptor binding and increased propensity for RBD up states. While adaptation to mink resulted in spike destabilization, the B.1.1.7 (UK) spike balanced stabilizing and destabilizing mutations. A local destabilizing effect of the RBD E484K mutation was implicated in resistance of the B.1.1.28/P.1 (Brazil) and B.1.351 (South Africa) variants to neutralizing antibodies. Our studies revealed allosteric effects of mutations and mechanistic differences that drive either inter-species transmission or escape from antibody neutralization. ....

New York , United States , United Kingdom , South Africa , Leica Microsystems , Joshua Mendez , Led Eng , Mahira Aragon , Eugene Chua , Rr Core Team , Duke Research Computing , National Institute Of Allergy , Duke Regional Biocontainment Laboratory , Electron Microscopy Sciences , Simons Foundation , Ge Healthcare , National Center , Defense Advanced Projects Agency , National Institutes Of Health , Sera Care Life Sciences , York Structural Biology Center , Common Fund Transformative High Resolution Cryo , Foundation For Statistical Computing , Simons Electron Microscopy Center , Duke University , C Terminal Twinstrep ,