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Eric Topol, a physician-scientist, discusses the transformative potential of AI in medicine in this TED podcast. He explains how AI models can interpret medical images as effectively or better than human experts, and even identify elements that humans cannot see. The integration of AI into healthcare has the potential to
Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry. Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry.
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With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. The EBI AlphaFold Protein Structure Database (for example) contains over 230 million structures. In this study, these data have been analyzed to find all human proteins containing (or predicted to contain) the cytosolic glu...
Post-translational modifications (PTMs) provide a rapid mechanism that enables protein phenotypic diversity so that proteins can react to external and internal disturbances and regulate cellular activity. This Biotech Brief discusses tools and methods that are employed in detecting these sub-stoichiometric and elusive protein modifiers, including mass spectrometry, antibody, artificial intelligence, ubiquitin-clipping, and specific uncaging-assisted biotinylation-based approaches. The article also discusses challenges in detecting PTMs, such as the development of PTM antibodies with high speci...