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Servier announce updated overall survival results of exploratory TASCO1 phase II study of LONSURF + bevacizumab in a first-line setting for patients with unresectable mCRC non-eligible for intensive therapy


(2)
Servier announced today updated results from the exploratory phase II TASCO1 study evaluating LONSURF
(trifluridine/tipiracil) bevacizumab and capecitabine bevacizumab (C-B) in a first-line setting for patients with unresectable metastatic colorectal cancer (mCRC) who are non-eligible for intensive therapy.
1 The data were announced today during an oral presentation at the 2021 ASCO Gastrointestinal Cancers Symposium (ASCO-GI). Patients with mCRC who are not eligible for chemotherapy face a large unmet need, with fewer treatment options available to them and lower survival rates.
Colorectal cancer (CRC) makes up 9.7% of total global cancer cases, with almost 1.4 million new cases of CRC each year.
2 In Europe, CRC is the second most common cause of death due to cancer, and those with a metastatic disease have a 5-year survival rate of just 11%. ....

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Welcome To IANS Live - ENTERTAINMENT - Urvashi Rautela goes '10 shades darker' for project


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Mumbai, Jan 13 (IANS) Actress and former beauty queen Urvashi Rautela has gone 10 shades darker than her original skin tone for an upcoming project.
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Update: 13-January-2021 ....

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F. Hoffmann-La Roche Ltd: Roche to present updated data confirming Tecentriq in combination with Avastin substantially improves overall survival in people with the most common form of liver cancer


F. Hoffmann-La Roche Ltd: Roche to present updated data confirming Tecentriq in combination with Avastin substantially improves overall survival in people with the most common form of liver cancer
19.2
6.9
18.1
Tecentriq + Avastin (n=133)
24.0
(0.35-0.80)
Median follow-up: 15.6 months.
CR, complete response; DOR, duration of response; HR, hazard ratio; NE, not estimable; ORR, objective response rate; OS, overall survival; PFS, progression free response; PR, partial response; SD, stable disease.
See below for OS data from the primary analysis.
About the IMbrave150 study
IMbrave150 is a global Phase III, multicentre, open-label study of 501 people with unresectable HCC who had not received prior systemic therapy. People were randomised 2:1 to receive the combination of Tecentriq and Avastin or sorafenib. Tecentriq was administered intravenously (IV), 1200 mg on day 1 of each 21-day cycle, and Avastin was administered IV, 15 mg/kg on day ....

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Welcome To IANS Live - ENTERTAINMENT - Gauahar Khan on marriage: Happy we didn't take time to take that plunge


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New Delhi, Jan 10 (IANS) Just-married Gauahar Khan is happy that she did not waste time before taking the plunge with Zaid Darbar.
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Update: 10-January-2021 ....

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