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Intravenous Vitamin C for Patients Hospitalized With COVID-19

Two randomized clinical trials were harmonized to compare the effect of vitamin C vs control on outcomes in hospitalized patients with COVID-19 who were critica ....

United States , New Delhi , Saudi Arabia , Krung Thep Mahanakhon , Western Australia , City Of , United Kingdom , National University , San Francisco , South Australia , New Zealand , Northern Ireland , France General , Wellington Hills , Northern Territory , Ar Riya , British Columbia , Tamil Nadu , Sri Lanka , New South Wales , National University Of Singapore , Singapore General , New Zealand General , Noord Holland , Bram Rochwerg , Paulr Mouncey ,

Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial examines the effect of initiation of a renin-angiotensin system inhibitor (ACE inhibitor or an angiotensin receptor blocker) on t ....

Eteläuomen Läi , Saudi Arabia , Sri Lanka , University Of Minnesota , United States , San Francisco , New South Wales , City Of , United Kingdom , Krung Thep Mahanakhon , British Columbia , France General , New Zealand , Western Australia , Northern Ireland , South Australia , London School , Montigny Le Bretonneux , Ar Riya , New Zealand General , Îe De France , National University , The Netherlands , Marlenes Santos , Frank Gommans , Bryanj Mcverry ,

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19

This exploratory study of a multiplatform randomized trial investigating the effects of therapeutic-dose heparin in early-pandemic hospitalized COVID-19 patient ....

United States , New Zealand , Province Of Ontario , Western Australia , Bruxelles Capitale , Christopher Seymour , Monte Carlo , Meredian Bio , Ewanc Goligher , Lyonelg Israels Research , Multifactorial Adaptive Platform Trial For Community , Global Coalition For Adaptive Research , University Of Maryland , Boehringer Ingelheim , Australian National Health , Amag Pharmaceuticals , Imperial Biomedical Research Centre , Rapid Research , National Institute , Bayer Pharmaceuticals , Cancercare Manitoba Foundation , Hospital Foundation , Pfizer Alliance , Hematology University Of Manitoba , National Institutes Of Health , Lifearc Foundation ,

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial | Critical Care Medicine | JAMA

This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-te ....

United Kingdom , South Australia , France General , City Of , British Columbia , United States , Western Australia , San Francisco , New Zealand General , New Zealand , Estado De Pernambuco , National University , Eteläuomen Läi , Sao Paulo , Sri Lanka , Ar Riya , Saudi Arabia , Îe De France , Krung Thep Mahanakhon , Montigny Le Bretonneux , Charlottea Bradbury , Srinivas Murthy , Alistaird Nichol , Herman Goossens , Kathrynm Rowan , Marcjm Bonten ,

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive care u ....

Nordrhein Westfalen , City Of , United Kingdom , France General , British Columbia , United States , Bedford Park , South Australia , Flinders University , Western Australia , San Francisco , New Zealand General , New Zealand , Estado De Pernambuco , National University Of Singapore , Singapore General , Monte Carlo , Eteläuomen Läi , Sao Paulo , Sri Lanka , Ar Riya , Saudi Arabia , Northern Ireland , Bruxelles Capitale , Îe De France , Krung Thep Mahanakhon ,