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CNIC scientists identify essential factors for limb formation

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), have identified Meis transcription factors as essential biomolecules for the formation and antero-posterior patterning of the limbs during embryonic development. ....

Recherches Cliniques , Investigaciones Cardiovasculares , Irene Delgado , Miguel Torres , Nature Communications , Genetic Control Of Organ Development , Institut De Recherches Cliniques Montr , Genetic Control , Morgan Development , Sonic Hedgehog , Molecular Biology , ஐரீந் டெல்கடோ , மிகுவல் டோரஸ் , இயற்கை தகவல்தொடர்புகள் , ஜெநெடிக் கட்டுப்பாடு , ஆர்கந் வளர்ச்சி , சோனிக் முள்ளம்பன்றி ,

New tech predicts chemotherapy effectiveness after one treatment

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IMAGE: Quing Zhu s lab developed this handheld ultrasound-guided diffuse optical tomography system which consists of a 10-centimeter probe and a near-infrared system that takes data noninvasively from the breast from nine.
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Credit: (Quing Zhu lab)
While early detection of breast cancer is critical, early prediction of how well the neoadjuvant chemotherapy treatment before surgery is working also may provide a window of opportunity when treatment could be altered and have a big impact on the patient s quality of life.
An interdisciplinary team of researchers at Washington University in St. Louis has found that combining data from tumor biomarkers, ultrasound, and ultrasound-guided diffuse optical tomography (DOT) after a patient s first cycle of pre-surgical neoadjuvant chemotherapy provided a highly accurate prediction of how the tumor was responding to the treatment. The results from a clinical trial at Washington University School ....

Quing Zhu , Breast Cancer Research , School Of Medicine , Office Of Technology Management , Mckelvey School Of Engineering , Washington University School Of Medicine , Washington University In St , Washington University , Washington University School , Barnes Jewish Hospital , Treatment May , Mckelvey School , Technology Management , Biomedical Environmental Chemical Engineering , Breast Cancer , Technology Engineering Computer Science , குயிங் ஜு , மார்பக புற்றுநோய் ஆராய்ச்சி , பள்ளி ஆஃப் மருந்து , அலுவலகம் ஆஃப் தொழில்நுட்பம் மேலாண்மை , ம்க்கெல்வேய் பள்ளி ஆஃப் பொறியியல் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , வாஷிங்டன் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , களஞ்சியங்கள் நகை மருத்துவமனை ,

The dream team: Scientists find drug duo that may cure COVID-19 together

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IMAGE: Researchers screened a panel of drugs that are already approved for clinical use and identified two drugs that provided effective SARS-CoV-2 suppression: cepharanthine and nelfinavir
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Credit: Louis Reed on Unsplash
COVID-19 continues to claim lives across the world and is infecting millions more. Although several vaccines have recently become available, making significant strides towards preventing COVID-19, what about the treatment of those who already have the infection? Vaccines aren t 100% effective, highlighting the need now more than ever for effective antiviral therapeutics. Moreover, some people can t receive vaccines due to health issues, and new variants of SARS-CoV-2, the virus that causes COVID-19, that can penetrate vaccine-conferred immunity, are being reported, indicating that we need to think beyond prevention. ....

United Kingdom , Kouji Kuramochi , Shin Aoki , Hirofumi Ohashi , Koichi Watashi , Tomohiro Tanaka , Japanese Cancer Association , Research Center , Department Of Virology , National Institute Of Infectious Diseases , Japanese National Institute Of Infectious Diseases , Japanese Society Of Hepatology , Department Of Applied Biological Sciences , International Symposium On Hepatitisc Virus , Vaccine Development , Tokyo University Of Science , Division Of Drug Development , Japanese Society For Virology , Tokyo University , Visiting Professor Koichi Watashi , Professor Shin Aoki , Professor Kouji Kuramochi , Assistant Professor Tomohiro , Nobel Prize , Professor Koichi Watashi , Drug Development ,

Expression of 'fat' genes correlate with metabolic, behavioral changes linked to obesity

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A collection of genetic variants influences the expression of obesity-associated genes in both the brain and fat tissue, according to a new study from researchers at the University of Chicago. The research team found that changes in the expression of the obesity-associated genes correlated with both metabolic and behavioral changes, suggesting that these variants produce combinatorial effects that increase the risk of obesity. The results, which scientists hope will lead to better understanding of the mechanisms that make some people more susceptible to obesity, were published June 4 in
The strongest genetic association with obesity in humans corresponds to a group of genetic variants within a gene called FTO. Over 40% of humans have one copy of these variants and 16% have two copies, which increase their risk of becoming obese by 70%. Despite their prominent impact, the mechanisms by which these common variants lead to obesity remain unclear. ....

Iain Williamson , Mengjie Chen , Sharono Jensen Cody , Ivy Aneas , Ameliac Joslin , Noboruj Sakabe , Matthew Potthoff , Carole Ober , Kathrynm Farris , Melina Claussnitzer , Wendya Bickmore , Kyleh Flippo , Grazyna Bozek , Qi Zhang , Broad Institute , National Institutes Of Health , University Unit , University Of Edinburgh , University Of Iowa Carver College Medicine , University Of Chicago , Novo Nordisk Foundation Challenge Grant , Stanford University , Human Genetics , National Institutes , Nasa Sinnott Armstrong , Iowa Carver College ,

Researchers reveal the inner workings of a viral DNA-packaging motor

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IMAGE: A trio of studies has revealed how a viral DNA packaging motor works, potentially providing insights for new therapeutics or synthetic molecular machines. Each of five proteins scrunches up in.
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Credit: Joshua Pajak, Duke University
DURHAM, N.C. - A group of researchers have discovered the detailed inner workings of the molecular motor that packages genetic material into double-stranded DNA viruses. The advance provides insight into a critical step in the reproduction cycle of viruses such as pox- herpes- and adeno-viruses. It could also give inspiration to researchers creating microscopic machines based on naturally occurring biomotors. ....

San Diego , United States , Marc Morais , Emilio Reyes Aldrete , Mark White , Wei Zhao , Gaurav Arya , Paul Jardine , Michael Woodson , Wei Zhang , Shelley Grimes , Paulj Jardine , Briana Kelch , Marka White , Brendanj Hilbert , Dwight Anderson , Marcc Morais , Joshua Pajak , Bryonp Mahler , De Shaw Research , National Institutes Of Health , Nucleic Acids Research , National Science Foundation , University Of Texas Medical Branch , Pittsburgh Supercomputing Center , San Diego Supercomputer Center ,