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Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors


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This news release, originally issued by Diamond Light Source, describes a template for how to develop directly-acting antivirals that would combat COVID-19. The study focused on a specific part of the Nsp3 gene that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. Researchers from the University of California used the Highly Automated Macromolecular Crystallography (AMX) and the Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines at the National Synchrotron Light Source II (NSLS-II) to characterize the molecular structure of proteins involved in this mechanism. The beamlines ultrasmall yet powerful x-rays and rapid sample mounting automation enabled the researchers to collect hundreds of high-resolution datasets per eight-hour shift. NSLS-II is a U.S. Department of Energy (DOE) Office of Science User Facility at DOE’s Brookhaven National Laboratory that offers a comprehensive suite of life science research capabilities ....

United States , University Of California San Francisco , Cara Laasch , University Of California , University Of Oxford , Us Department Of Energy , Office Of Science User Facility , National Synchrotron Light Source , Structural Biology Consortium , Brookhaven National Laboratory , Diamond Light Source , Highly Automated Macromolecular Crystallography , Science User Facility , National Laboratory , Fragment Screen Points Way , Beamline Scientist , Science Advances , Biology Consortium , California San , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , எங்களுக்கு துறை ஆஃப் ஆற்றல் , அலுவலகம் ஆஃப் அறிவியல் பயனர் வசதி , தேசிய ஒத்திசைவு ஒளி மூல ,

Massive fragment screen points way to new SARS-CoV-2 inhibitors


Experiment with 2533 fragments compounds generates chemical map to future antiviral agents 
Principal Beamline Scientist on I04, Frank von Delft. 
New research published in
Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This part of the virus’s machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking it with a drug would have the same effect.   ....

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Compound Map provides Foundation for SARS-CoV-2 Inhibitors Discovery


Apr 15 2021 Read 7 Times
A new international study(1) has provided a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This part of the virus’s machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking it with a drug would have the same effect. 
The study involved a crystallographic fragment screen of the Nsp3 Mac1 protein by an open science collaboration between researchers from the University of Oxford, the XChem platform at Diamond Light Source, the UK’s national synchrotron and researchers from the QCRG Structural Biology Consortium at the University of California San Francisco.  The internationa ....

United Kingdom , University Of Oxford , Structural Biology Consortium , University Of California San Francisco , Diamond Light Source , Biology Consortium , California San , Principal Beamline Scientist , Advances Paper , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , வைரம் ஒளி மூல , உயிரியல் கூட்டமைப்பு , கலிஃபோர்னியா சான் ,

Massive fragment screen points way to new SARS-CoV-2 inhibitors

Massive fragment screen points way to new SARS-CoV-2 inhibitors
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , Jessicak Peters , Jasone Gestwicki , Jamess Fraser , Matteop Ferla , Daren Fearon , Ivan Ahel , Marion Schuller , Nadia Herrera , Dominiqueh Smith , Galenj Corey , Ursula Schulze Gahmen , Johannes Gregor Matthias , Justint Biel , Michaelc Thompson , Victorl Rangel , Ailsaj Powell , Taiasean Wu , Tylerj Gorrie , Jenniferl Wierman , Tristanw Owens , Kang Zhu , Oleg Fedorov , Rachaele Skyner , Roberto Efra , Natalia Jura ,

New PTSD Biotypes Enable Improved Tests


New PTSD Biotypes Enable Improved Tests
by Colleen Fleiss on 
January 24, 2021 at 11:26 PM
New and distinct biotypes for post-traumatic stress disorder, the first of their kind for any psychological disorder have been discovered by PTSD Systems Biology Consortium, led by scientists from the Walter Reed Army Institute of Research.
Publishing their work in Molecular Psychiatry in a manuscript first authored by WRAIR s Dr. Ruoting Yang, researchers used blood tests from male, combat-exposed veterans across a three year period to identify two PTSD biotypes, G1 characterized by mild, inherent co-morbidities typical of PTSD and G2 which includes more severe symptoms typical of PTSD and report more physical distress with differing genetic markers and underlying mechanisms of disease. ....

Ruoting Yang , Walter Reed Army Institute Of Research , Systems Biology Consortium , Biology Consortium , Walter Reed Army Institute , Molecular Psychiatry , Post Traumatic Stress Disorder , வால்டர் நாணல் இராணுவம் நிறுவனம் ஆஃப் ஆராய்ச்சி , அமைப்புகள் உயிரியல் கூட்டமைப்பு , உயிரியல் கூட்டமைப்பு , வால்டர் நாணல் இராணுவம் நிறுவனம் , மூலக்கூறு மனநல மருத்துவம் , போஸ்ட் அதிர்ச்சிகரமான மன அழுத்தம் கோளாறு ,